Commensal Bifidobacterium promotes antitumor immunity and facilitates anti–PD-L1 efficacy
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Summary
Comparison of melanoma growth in mice harboring distinct commensal microbiota and observed differences in spontaneous antitumor immunity, suggests that manipulating the microbiota may modulate cancer immunotherapy.
- Type
- article
- Published
- 2015-11-05
- Cited by
- 3,556
- References
- 48
- Access
- Open access
- OpenAlex
- https://openalex.org/W2185075416
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:206638876
Keywords
Bifidobacterium, Immunity, Immune system, Immunology, Microbiology
References
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- An immune-active tumor microenvironment favors clinical response to ipilimumab
- PD-1 blockade induces responses by inhibiting adaptive immune resistance
- Intercellular adhesion molecule-1-dependent stable interactions between T cells and dendritic cells determine CD8+ T cell memory.
- The intestinal microbiota modulates the anticancer immune effects of cyclophosphamide
- The microbial metabolites, short chain fatty acids, regulate colonic Treg cell homeostasis
- Antigen Processing and Remodeling of the Endosomal Pathway: Requirements for Antigen Cross-Presentation
- Interferon-gamma is an autocrine mediator for dendritic cell maturation.
- Interactions between the microbiota and the immune system
- QIIME allows analysis of high-throughput community sequencing data
- Improved Survival with Ipilimumab in Patients with Metastatic Melanoma
Cited by
- The gut microbiota and inflammatory bowel disease
- Taking it Personally: Personalized Utilization of the Human Microbiome in Health and Disease.
- A Mini-Review for Cancer Immunotherapy: Molecular Understanding of PD-1/PD-L1 Pathway & Translational Blockade of Immune Checkpoints
- Development of oral cancer vaccine using recombinant Bifidobacterium displaying Wilms’ tumor 1 protein
- The microbiome and hepatobiliary-pancreatic cancers.
- The inflammatory microenvironment and microbiome in prostate cancer development
- Precision medicine using microbiota
- Anti-PD1 in the wonder-gut-land
- Actinobacteria: A relevant minority for the maintenance of gut homeostasis.
- Cancer Immunotherapy: A Focus on the Regulation of Immune Checkpoints
- Fecal microbiota transplantation: a promising strategy in preventing the progression of non-alcoholic steatohepatitis and improving the anti-cancer immune response
- Compositional and temporal changes in the gut microbiome of pediatric ulcerative colitis patients are linked to disease course
- The use of microbiome restoration therapeutics to eliminate intestinal colonization with multi-drug resistant organisms
- Association of Tumor Microenvironment T-Cell Repertoire and Mutational Load With Clinical Outcome After Sequential Checkpoint Blockade in Melanoma
- A bilateral tumor model identifies transcriptional programs associated with patient response to immune checkpoint blockade
- Probiotic Engineering and Targeted Sonoimmuno‐Therapy Augmented by STING Agonist
- Exploring the Potential of Humoral Immune Response to Commensal Bifidobacterium as a Biomarker for Human Health, including Both Malignant and Non-Malignant Diseases: A Perspective on Detection Strategies and Future Directions
- Antigen Presentation in Transplantation
- Microbiome: Commensals promote anticancer immunotherapy
- Beating Cancer with a Gut Feeling.
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