CXCL12-CXCR4 engagement is required for migration of cutaneous dendritic cells.
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Summary
It is demonstrated that CXCL12-CXCR4 engagement on cutaneous DCs plays a crucial role in the initiation of skin immune response by enhancing cutaneousDC migration.
- Type
- article
- Published
- 2007-10-01
- Cited by
- 272
- References
- 47
- Access
- Open access
- OpenAlex
- https://openalex.org/W1973442022
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:31921010
Keywords
Langerin, CD11c, C-C chemokine receptor type 7, Chemokine receptor, Immunology
References
- Dendritic cells and the control of immunity
- Cutting edge: secondary lymphoid-tissue chemokine (SLC) and CC chemokine receptor 7 (CCR7) participate in the emigration pathway of mature dendritic cells from the skin to regional lymph nodes.
- Enhancement of the T140-based pharmacophores leads to the development of more potent and bio-stable CXCR4 antagonists.
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- Stromal-cell derived factor is expressed by dendritic cells and endothelium in human skin.
- Epidermal langerhans cell-deficient mice develop enhanced contact hypersensitivity.
- Involvement of the CXCL12/CXCR4 pathway in the recovery of skin following burns.
- Who is really in control of skin immunity under physiological circumstances – lymphocytes, dendritic cells or keratinocytes?
- Thromboxane A2 modulates interaction of dendritic cells and T cells and regulates acquired immunity
- Rapid and coordinated switch in chemokine receptor expression during dendritic cell maturation
- BLC expression in pancreatic islets causes B cell recruitment and lymphotoxin-dependent lymphoid neogenesis.
- Prostaglandin E2 is a key factor for CCR7 surface expression and migration of monocyte-derived dendritic cells.
- Epidermal Viral Immunity Induced by CD8α+ Dendritic Cells But Not by Langerhans Cells
- Regulation of dendritic cell migration and adaptive immune response by leukotriene B4 receptors: a role for LTB4 in up-regulation of CCR7 expression and function.
- The role of chemokines in regulating cell migration during humoral immune responses.
- Dynamics and function of Langerhans cells in vivo: dermal dendritic cells colonize lymph node areas distinct from slower migrating Langerhans cells.
- Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1
- Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development
- Prostaglandin E2–EP4 signaling initiates skin immune responses by promoting migration and maturation of Langerhans cells
Cited by
- High expression of PGE2 enzymatic pathways in cervical (pre)neoplastic lesions and functional consequences for antigen-presenting cells
- Cellular MRI as a suitable, sensitive non-invasive modality for correlating in vivo migratory efficiencies of different dendritic cell populations with subsequent immunological outcomes.
- Mice deficient in heparanase exhibit impaired dendritic cell migration and reduced airway inflammation
- Interplay between Inflammatory Responses and Lymphatic Vessels
- Interactions of immune cells and lymphatic vessels.
- Rôle de la molécule CD47 dans l’homéostasie du système immunitaire
- Innate immune potential of primary lymphatic endothelial cells
- Skin dendritic cells : activation, maturation and migration
- CXCR4 as a target for preclinical Positron Emission Tomography of cancer
- Function of Hypoxia Inducible Factor HIF1α in Dendritic Cells and Macrophages
- Cellular and molecular mechanisms of action of the novel adjuvant polyphosphazene
- Crosstalk Between PKA and Epac Regulates the Phenotypic Maturation and Function of Human Dendritic Cells
- Influence of hypoxia-inducible factor 1α on dendritic cell differentiation and migration
- Studies on molecular regulation of inflammation in cutaneous lupus erythematosus
- Addition of CpG ODN and Poly (I:C) to a standard maturation cocktail generates monocyte-derived dendritic cells and induces a potent Th1 polarization with migratory capacity
- Neutrophils Exhibit Differential Requirements for Homing Molecules in Their Lymphatic and Blood Trafficking into Draining Lymph Nodes
- Dibutyl Phthalate (DBP) Induced Thymic Stromal Lymphopoietin (TSLP) Is Required for Th2 Contact Hypersensitivity Responses
- Electric signals regulated immunomodulation and wound healing
- Mechanisms and Consequences of Dendritic Cell Migration
- Stress-induced production of chemokines by hair follicles regulates the trafficking of dendritic cells in skin
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