HIV nonprogressors preferentially maintain highly functional HIV-specific CD8+ T cells.
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Summary
The quality of the HIV-specific CD8(+) T-cell functional response serves as an immune correlate of HIV disease progression and a potential qualifying factor for evaluation of HIV vaccine efficacy.
- Type
- article
- Published
- 2006-06-15
- Cited by
- 1,976
- References
- 37
- Access
- Open access
- OpenAlex
- https://openalex.org/W2160925670
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:1983641
Keywords
Human immunodeficiency virus (HIV), Biology, Virology, Cytotoxic T cell, Immunology
References
- Loss of HIV-1–specific CD8+ T Cell Proliferation after Acute HIV-1 Infection and Restoration by Vaccine-induced HIV-1–specific CD4+ T Cells
- HIV-1-specific CD4+ T cells are detectable in most individuals with active HIV-1 infection, but decline with prolonged viral suppression
- Tat-specific cytotoxic T lymphocytes select for SIV escape variants during resolution of primary viraemia
- Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndrome
- Maintenance of Large Numbers of Virus-Specific CD8+ T Cells in HIV-Infected Progressors and Long-Term Nonprogressors
- Skewed maturation of memory HIV-specific CD8 T lymphocytes
- Virus-specific cytotoxic T-lymphocyte responses select for amino-acid variation in simian immunodeficiency virus Env and Nef
- Sensitive and viable identification of antigen-specific CD8+ T cells by a flow cytometric assay for degranulation.
- Late escape from an immunodominant cytotoxic T-lymphocyte response associated with progression to AIDS
- HIV-1-specific immune responses in subjects who temporarily contain virus replication after discontinuation of highly active antiretroviral therapy.
- Correlates of immune protection in HIV-1 infection: what we know, what we don't know, what we should know
- HIV-specific CD8+ T cell proliferation is coupled to perforin expression and is maintained in nonprogressors
- The Differential Ability of HLA B*5701+ Long-Term Nonprogressors and Progressors To Restrict Human Immunodeficiency Virus Replication Is Not Caused by Loss of Recognition of Autologous Viral gag Sequences
- Influence of HLA-B57 on clinical presentation and viral control during acute HIV-1 infection
- Influence of combinations of human major histocompatibility complex genes on the course of HIV–1 infection
- Analysis of Total Human Immunodeficiency Virus (HIV)-Specific CD4+ and CD8+ T-Cell Responses: Relationship to Viral Load in Untreated HIV Infection
- HIV-1-specific IFN-gamma/IL-2-secreting CD8 T cells support CD4-independent proliferation of HIV-1-specific CD8 T cells.
- Flow cytometric analysis of vaccine responses: how many colors are enough?
- Quantifiable cytotoxic T lymphocyte responses and HLA-related risk of progression to AIDS.
- Long-term kinetics of T cell production in HIV-infected subjects treated with highly active antiretroviral therapy.
Cited by
- Toll-like receptor agonists influence the magnitude and quality of memory T cell responses after prime-boost immunization in nonhuman primates
- Human Immunodeficiency Virus Type 1 Controllers but Not Noncontrollers Maintain CD4 T Cells Coexpressing Three Cytokines
- HIV Gag p24 specific responses secreting IFN-gamma and/or IL-2 in treatment-naïve individuals in acute infection early disease (AIED) are associated with low viral load.
- Flow cytometry and the future of vaccine development
- Poor Lymphoproliferative Responses with Low Proportion of Gag-Specific CD8 TEMRA Cells in HIV-1-Infected Patients Showing Immunological and Virological Discordance Despite Prolonged Suppression of Plasma Viremia
- Experimental depletion of CD8+ cells in acutely SIVagm-Infected African Green Monkeys results in increased viral replication
- Comparative analysis of immune responses induced by vaccination with SIV antigens by recombinant Ad5 vector or plasmid DNA in rhesus macaques.
- Nef-specific CD45RA+ CD8+ T cells secreting MIP-1β but not IFN-γ are associated with nonprogressive HIV-1 infection
- CD4+ T Cells Modulate Expansion and Survival but Not Functional Properties of Effector and Memory CD8+ T Cells Induced by Malaria Sporozoites
- The combination of 4‐1BBL and CD40L strongly enhances the capacity of dendritic cells to stimulate HIV‐specific T cell responses
- SIV antigen immunization induces transient antigen-specific T cell responses and selectively activates viral replication in draining lymph nodes in retroviral suppressed rhesus macaques
- Shelterin Dysfunction and p16INK4a-Mediated Growth Inhibition in HIV-1-Specific CD8 T Cells
- Evaluating Cellular Polyfunctionality with a Novel Polyfunctionality Index
- Hiv-1 Control after Transient Antiretroviral Treatment Initiated in Primary Infection: Role of Patient Characteristics and Effect of Therapy
- The Phenotype of the Cryptococcus-Specific CD4+ Memory T-Cell Response Is Associated With Disease Severity and Outcome in HIV-Associated Cryptococcal Meningitis
- CD8 T-Cells from Most HIV-Infected Patients Lack Ex Vivo HIV-Suppressive Capacity during Acute and Early Infection
- Different antigen processing activities in dendritic cells, macrophages and monocytes lead to uneven production of HIV epitopes and affect CTL recognition
- Reactivation Kinetics of HIV-1 and Susceptibility of Reactivated Latently Infected CD4+ T Cells to HIV-1-Specific CD8+ T Cells
- HIV-Specific CD8+ T Cell–Mediated Viral Suppression Correlates With the Expression of CD57
- HIV-Specific CD8 T Cells Producing CCL-4 Are Associated With Worse Immune Reconstitution During Chronic Infection
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