Conservation of the hedgehog/patched signaling pathway from flies to mice: induction of a mouse patched gene by Hedgehog.
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Summary
A mouse homolog of ptc is identified which in many tissues is transcribed near cells making either Sonic or Indian hedgehog, and ectopic Sonic hedgehog expression in the mouse central nervous system induces ptc transcription.
- Type
- article
- Published
- 1996-02-01
- Cited by
- 891
- References
- 63
- Access
- Open access
- OpenAlex
- https://openalex.org/W2160889747
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:7177376
Keywords
Patched, Hedgehog, Biology, Hedgehog signaling pathway, Sonic hedgehog
References
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- A quantitative analysis of the effect of excision of the AER from the chick limb-bud.
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- A simple method for displaying the hydropathic character of a protein.
- Regulation of furrow progression in the Drosophila eye by cAMP-dependent protein kinase A
- The Drosophila patched gene encodes a putative membrane protein required for segmental patterning.
- Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity.
- Contrasting distributions of patched and hedgehog proteins in the Drosophila embryo.
- Convergence and divergence in the evolution of transport proteins
- Chemotropic guidance of developing axons in the mammalian central nervous system
- A functionally conserved homolog of the Drosophila segment polarity gene hh is expressed in tissues with polarizing activity in zebrafish embryos.
Cited by
- The role of the hedgehog/patched signaling pathway in epithelial stem cell proliferation: from fly to human
- Mechanisms for the development of esophageal atresia.
- Molecular mechanisms underlying limb anomalies associated with cholesterol deficiency during gestation: implications of Hedgehog signaling.
- A strong nerve dependence of sonic hedgehog expression in basal cells in mouse taste bud and an autonomous transcriptional control of genes in differentiated taste cells.
- Wnt and hedgehog signaling pathways in bone development.
- Molecular biology of basal and squamous cell carcinomas.
- Intercellular Signaling Pathways Active During Intervertebral Disc Growth, Differentiation, and Aging
- Spatially distinct functions of PAX6 and NKX2.2 during gliogenesis in the ventral spinal cord.
- Hedgehog signaling regulates E-cadherin expression for the maintenance of the actin cytoskeleton and tight junctions.
- Glucocortiocoid Treatment of MCMV Infected Newborn Mice Attenuates CNS Inflammation and Limits Deficits in Cerebellar Development
- An ancient yet flexible cis-regulatory architecture allows localized Hedgehog tuning by patched/Ptch1
- Visceral endoderm and the primitive streak interact to build the fetal-placental interface of the mouse gastrula
- Ciliary gene RPGRIP1L is required for hypothalamic arcuate neuron development.
- Gene expression and regulation of hindbrain and spinal cord development.
- "Patch"-ing up the neurons: revival or enervation?
- The Hedgehog Signalling Pathway and its Role in Basal Cell Carcinoma
- Découverte et caractérisation pharmacologique de nouveaux antagonistes du récepteur smoothened : les composés mrt
- A SMO inhibitor drug reduces the progenitor cell's maintenance in the Drosophila hematopoietic organ: a novel model to study Chronic Myelogenous Leukemia relapse
- Endoderm Patterning in Zebrafish: Pancreas Development: A Dissertation
- Characterisation of a second patched gene in the zebrafish Danio rerio and the differential response of patched genes to Hedgehog signalling.
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