An ancient yet flexible cis-regulatory architecture allows localized Hedgehog tuning by patched/Ptch1
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Summary
This structure—one of the oldest cis-regulatory features discovered in animal genomes—explains how patched/Ptch1 can drive dramatic adaptations in animal morphology while maintaining its essential core function and may also suggest a general model for the evolutionary flexibility of conserved regulators and pathways.
- Type
- article
- Published
- 2016-05-03
- Cited by
- 36
- References
- 73
- OpenAlex
- https://openalex.org/W27146892
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:2790962
Keywords
Area density, Bar (unit), Replica, Carbon fibers, Curse of dimensionality
References
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- Dual roles for patched in sequestering and transducing Hedgehog.
- Determination and Inference of Eukaryotic Transcription Factor Sequence Specificity
- Regulation of pattern formation in the Drosophila hindgut by wg, hh, dpp, and en.
- Transgenic Wnt/TCF pathway reporters: all you need is Lef?
- Rapid Evolutionary Rewiring of a Structurally Constrained Eye Enhancer
Cited by
- How to tune an enhancer
- Complex cis-regulatory landscape of the insulin receptor gene underlies the broad expression of a central signaling regulator
- The Functionality and Evolution of Eukaryotic Transcriptional Enhancers.
- Galectin-1 induces invasion and the epithelial-mesenchymal transition in human gastric cancer cells via non-canonical activation of the hedgehog signaling pathway
- Functional regulatory evolution outside of the minimal even-skipped stripe 2 enhancer
- Patched Together: cis-Regulatory Logic of the Hedgehog Response.
- Nuclear microenvironments modulate transcription from low-affinity enhancers
- Polycomb and Trithorax Group Genes in Drosophila
- Using synthetic biology to study gene regulatory evolution.
- Phenotype loss is associated with widespread divergence of the gene regulatory landscape in evolution
- Analysis of the transcriptional logic governing differential spatial expression in Hh target genes
- Tuned polymerization of the transcription factor Yan limits off-DNA sequestration to confer context-specific repression
- Studying transcriptional enhancers: the founder fallacy, validation creep, and other biases
- Multi-enhancer transcriptional hubs confer phenotypic robustness
- Regulation of GLI1 by cis DNA elements and epigenetic marks
- Division of labor in honey bees is associated with transcriptional regulatory plasticity in the brain
- Genomic architecture of Shh-dependent cochlear morphogenesis
- Redundant and Cryptic Enhancer Activities of the Drosophila yellow Gene
- GLI transcriptional repression regulates tissue-specific enhancer activity in response to Hedgehog signaling
- The formation of the thumb requires direct modulation of Gli3 transcription by Hoxa13
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