Structure, mechanism and regulation of peroxiredoxins.
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Summary
Using crystal structures, a detailed catalytic cycle has been derived for typical 2-Cys Prxs, including a model for the redox-regulated oligomeric state proposed to control enzyme activity.
- Type
- review
- Published
- 2003-01-01
- Cited by
- 2,483
- References
- 57
- OpenAlex
- https://openalex.org/W2158496331
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:14050580
Keywords
Sulfenic acid, Cysteine, Biochemistry, Peroxiredoxin, Enzyme
References
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- Calcium-activated potassium transport and high molecular weight forms of calpromotin.
- The isolation and purification of a specific "protector" protein which inhibits enzyme inactivation by a thiol/Fe(III)/O2 mixed-function oxidation system.
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- Antioxidant and redox regulation of genes
- Reconstitution of Ca(2+)-dependent K+ transport in erythrocyte membrane vesicles requires a cytoplasmic protein.
- Peroxynitrite reductase activity of bacterial peroxiredoxins
- Purification and characterization of a substrate protein for mitochondrial ATP-dependent protease in bovine adrenal cortex.
- Variants of peroxiredoxins expression in response to hydroperoxide stress.
- Crystal structure of a multifunctional 2-Cys peroxiredoxin heme-binding protein 23 kDa/proliferation-associated gene product.
- Identification of a New Type of Mammalian Peroxiredoxin That Forms an Intramolecular Disulfide as a Reaction Intermediate*
- Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K‐12
- Tryparedoxin peroxidase of Leishmania donovani: molecular cloning, heterologous expression, specificity, and catalytic mechanism.
- Cyclophilin A Binds to Peroxiredoxins and Activates Its Peroxidase Activity*
- Routine preparation of air-dried negatively stained and unstained specimens on holey carbon support films: a review of applications.
- Metabolic Enzymes of Mycobacteria Linked to Antioxidant Defense by a Thioredoxin-Like Protein
Cited by
- Detection and proteomic identification of S-nitrosylated proteins in endothelial cells.
- Proteome analysis of human amnion and amniotic fluid by two‐dimensional electrophoresis and matrix‐assisted laser desorption/ionization time‐of‐flight mass spectrometry
- Redox Regulation of Human Thioredoxin Network
- Non-reductive modulation of chloroplast fructose-1,6-bisphosphatase by 2-Cys peroxiredoxin.
- The peroxiredoxin Tpx1 is essential as a H2O2 scavenger during aerobic growth in fission yeast.
- The Thioredoxin System of the Filamentous Fungus Aspergillus nidulans
- FOXO3A Regulates Peroxiredoxin III Expression in Human Cardiac Fibroblasts*
- Involvement of peroxiredoxin IV in the 16α‐hydroxyestrone‐induced proliferation of human MCF‐7 breast cancer cells
- Proteomic and oxidative stress analysis in human brain samples of Huntington disease.
- Synthèse et évalutaion de nouveaux composés organiques et phosphorés contre les effets des rayonnements ionisants. Etude de leur mécanisme d'action in vitro.
- Antioxidant Activity of the Yeast Mitochondrial One-Cys Peroxiredoxin Is Dependent on Thioredoxin Reductase and Glutathione In Vivo
- Mitochondrial peroxiredoxin 3 is more resilient to hyperoxidation than cytoplasmic peroxiredoxins
- Cloning, overexpression, purification, crystallization and preliminary X-ray diffraction analysis of an atypical two-cysteine peroxiredoxin (SAOUHSC_01822) from Staphylococcus aureus NCTC 8325.
- Peroxiredoxin IV protects cells from oxidative stress by removing H2O2 produced during disulphide formation
- Influence of iNOS and COX on peroxiredoxin gene expression in primary macrophages.
- Transcription factor GABP/NRF-2 controlling biogenesis of mitochondria regulates basal expression of peroxiredoxin V but the mitochondrial function of peroxiredoxin V is dispensable in the dog.
- The effects of chromium(VI) on the thioredoxin system: Implications for redox regulation
- Androgen-sensitive microsomal signaling networks coupled to the proliferation and differentiation of human prostate cancer cells.
- Thiol-dependent Antioxidant Activity of Interphotoreceptor Retinoid-Binding Protein
- Short-term use of telmisartan attenuates oxidation and improves Prdx2 expression more than antioxidant β-blockers in the cardiovascular systems of spontaneously hypertensive rats
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