Cyclic-GMP-AMP Is An Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA
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Summary
Cytosolic DNA induces type I interferons and other cytokines that are important for antimicrobial defense but can also result in autoimmunity, and cGAMP functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolicDNA.
- Type
- article
- Published
- 2012-12-20
- Cited by
- 1,778
- References
- 21
- OpenAlex
- https://openalex.org/W2154171253
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:206545156
Keywords
Stimulator of interferon genes, Second messenger system, Guanosine, Biology, Cell biology
References
- Cytoplasmic DNA innate immune pathways
- Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response
- Earl Sutherland (1915-1975) and the Discovery of Cyclic AMP
- Structures of perfringolysin O suggest a pathway for activation of cholesterol-dependent cytolysins.
- Coordinated regulation of accessory genetic elements produces cyclic di-nucleotides for Vibrio cholerae virulence
- An epidemic of complex dysmorphologic syndromes in southeast Spain?
- c-di-AMP Secreted by Intracellular Listeria monocytogenes Activates a Host Type I Interferon Response
- STING is a direct innate immune sensor of cyclic-di-GMP
- One-flask Syntheses of c-di-GMP and the [Rp, Rp] and [Rp, Sp] Thiophosphate Analogs
- Lethally Hot Temperatures During the Early Triassic Greenhouse
- STING Specifies IRF3 phosphorylation by TBK1 in the Cytosolic DNA Signaling Pathway
- Dictyostelium uses the prokaryote messenger c-di-GMP to trigger stalk cell differentiation
- Cyclic GMP-AMP Synthase is a Cytosolic DNA Sensor that Activates the Type-I Interferon Pathway
- Bacterial nucleotide-based second messengers.
- Identification and Characterization of MAVS, a Mitochondrial Antiviral Signaling Protein that Activates NF-κB and IRF3
- Cyclic di-GMP Sensing via the Innate Immune Signaling Protein STING
- RNA Polymerase III Detects Cytosolic DNA and Induces Type-I Interferons Through the RIG-I Pathway
- Nucleic acid recognition by the innate immune system.
- The specific and essential role of MAVS in antiviral innate immune responses.
- RIG-I dependent sensing of poly(dA-dT) via the induction of an RNA polymerase III transcribed RNA intermediate
Cited by
- The binding of TBK1 to STING requires exocytic membrane traffic from the ER.
- SNX8 modulates innate immune response to DNA virus by mediating trafficking and activation of MITA
- Functional Profile of Human Cytomegalovirus Genes and Their Associated Diseases: A Review
- Diversity of pathogen sensors in dendritic cells.
- Suppressive Oligodeoxynucleotides Inhibit Cytosolic DNA Sensing Pathways: A Dissertation
- Characterization of Innate Immune Pathways in DNA Vaccine-Induced, Antigen-Specific Immune Responses: A Dissertation
- Newly Recognized Mendelian Disorders with Rheumatic Manifestations
- Enhanced immunostimulatory activity of cyclic dinucleotides on mouse cells when complexed with a cell‐penetrating peptide or combined with CpG
- PQBP1 is a Proximal Sensor of the cGAS-dependent Innate Response to HIV-1
- The Nature's Clever Trick for Making Cyclic Dinucleotide.
- ST2 and IL-33 differentially regulate the innate immune response to Streptococcus pneumoniae
- Blowing Off Steam: Virus Inhibition of cGAS DNA Sensing
- Cyclic GMP-AMP Synthase (cGAS) Is an Innate Immune DNA Sensor for Mycobacterium tuberculosis
- Transmission of innate immune signaling by packaging of cGAMP in viral particles
- Investigating inflammasome activation in response to Legionella pneumophila and its application to other bacterial pathogens
- Ubiquitination in the Antiviral Immune Response
- Crystal structure of the novel di-nucleotide cyclase from Vibrio cholerae (DncV) responsible for synthesizing a hybrid cyclic GMP-AMP
- Molecular cloning and functional characterization of porcine cyclic GMP-AMP synthase.
- Revving up cGAS
- The ER-associated protein ZDHHC1 is a positive regulator of DNA virus-triggered, MITA/STING-dependent innate immune signaling.
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