Enhanced immunostimulatory activity of cyclic dinucleotides on mouse cells when complexed with a cell‐penetrating peptide or combined with CpG
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Summary
Results presented herein indicate that 3′3′‐cGAMP, a recently identified bacterial CDN, is a superior stimulator of IFN genes ligand than cyclic‐di‐GMP in human PBMCs, suggesting that the immune‐stimulatory properties of CDNs can be augmented through peptide complexation or synergistic use with CpG oligonucleotide.
- Type
- article
- Published
- 2015-04-01
- Cited by
- 37
- References
- 42
- Access
- Open access
- OpenAlex
- https://openalex.org/W1481088827
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:4482536
Keywords
Biology, CpG site, Peptide, Cell biology, Cell
References
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Cited by
- Cyclic dinucleotides modulate human T‐cell response through monocyte cell death
- Stimulator of interferon genes (STING): A "new chapter" in virus-associated cancer research. Lessons from wild-derived mouse models of innate immunity.
- Cyclic dinucleotide (c-di-GMP, c-di-AMP, and cGAMP) signalings have come of age to be inhibited by small molecules.
- Development of CpG ODN Based Vaccine Adjuvant Formulations.
- The STING Ligand 3’3’-cGAMP Effectively Elicits Mucosal and Systemic Immunity Following Sublingual Immunization
- Mechanisms of transcriptional activation of the stimulator of interferon genes by transcription factors CREB and c-Myc
- Adjuvant Activity Enhanced by Cross-Linked CpG-Oligonucleotides in β-Glucan Nanogel and Its Antitumor Effect.
- Encapsulation of two different TLR ligands into liposomes confer protective immunity and prevent tumor development
- Involvement of sting-activating cyclic Di-nucleotides on T-cell differentiation and function: an unresolved issue
- A robust microparticle platform for a STING-targeted adjuvant that enhances both humoral and cellular immunity during vaccination
- STINGel: Controlled Release of a Cyclic Dinucleotide for Enhanced Cancer Immunotherapy
- Combination and inducible adjuvants targeting nucleic acid sensors
- Sustained protective immunity against Bordetella pertussis nasal colonization by intranasal immunization with a vaccine-adjuvant combination that induces IL-17-secreting TRM cells
- The Role of Nucleic Acid Sensing in Controlling Microbial and Autoimmune Disorders
- Acetalated Dextran Microparticles for Codelivery of STING and TLR7/8 Agonists
- Vaccine-induced protective immunity to Bordetella pertussis
- DAMP-Inducing Adjuvant and PAMP Adjuvants Parallelly Enhance Protective Type-2 and Type-1 Immune Responses to Influenza Split Vaccination
- Cyclic Dinucleotides Inhibit Osteoclast Differentiation Through STING‐Mediated Interferon‐β Signaling
- The triggers of the cGAS-STING pathway and the connection with inflammatory and autoimmune diseases.
- Agonists and inhibitors of the STING pathway: Potential agents for immunotherapy
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