Hi-C: A comprehensive technique to capture the conformation of genomes
Explore this paper's citation graph
Summary
A massively parallel survey of chromatin interaction provides the previously missing dimension of spatial context to other genomic studies and will provide a new perspective to studies of chromatin and its role in genome regulation in normal conditions and in disease.
- Type
- article
- Published
- 2012-05-29
- Cited by
- 1,157
- References
- 14
- Access
- Open access
- OpenAlex
- https://openalex.org/W2152605077
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:22531148
Keywords
Chromatin, Chromosome conformation capture, Computational biology, Sequencing by ligation, Genome
References
- An Oestrogen Receptor α-bound Human Chromatin Interactome
- Nuclear organization of active and inactive chromatin domains uncovered by chromosome conformation capture–on-chip (4C)
- Probabilistic modeling of Hi-C contact maps eliminates systematic biases to characterize global chromosomal architecture
- Chromosome Conformation Capture Carbon Copy (5C): a massively parallel solution for mapping interactions between genomic elements.
- Loss of silent-chromatin looping and impaired imprinting of DLX5 in Rett syndrome
- Spatial preservation of nuclear chromatin architecture during three-dimensional fluorescence in situ hybridization (3D-FISH).
- Integrative analysis of the cancer transcriptome
- Capturing Chromosome Conformation
- Comprehensive mapping of long range interactions reveals folding principles of the human genome
- Circular chromosome conformation capture (4C) uncovers extensive networks of epigenetically regulated intra- and interchromosomal interactions
- Chromosomal translocations are guided by the spatial organization of the genome
- The fractal globule as a model of chromatin architecture in the cell
- Organization of chromatin in the interphase mammalian cell.
- Chromosome territories.
Cited by
- The genomes of the aquarium sponges Tethya wilhelma and Tethya minuta (Porifera: Demospongiae)
- The Recombination Enhancer Modulates the Conformation of Chr. III in Budding Yeast: A Dissertation
- Chromosome Conformation of Human Fibroblasts Grown in 3-Dimensional Spheroids
- Disease Mechanisms in Rheumatology—Tools and Pathways: Defining Functional Genetic Variants in Autoimmune Diseases
- Comparison of the three-dimensional organization of sperm and fibroblast genomes using the Hi-C approach
- Recent Developments in Epigenetics of Acute and Chronic Kidney Diseases
- Chromosome domain architecture and dynamic organization of the fission yeast genome
- Deciphering regulation in eukaryotic cell: from sequence to function
- Transcription of Mammalian cis-Regulatory Elements Is Restrained by Actively Enforced Early Termination.
- Oestrogen-dependent regulation of gene expression by cohesin in breast cancer
- diffHic: a Bioconductor package to detect differential genomic interactions in Hi-C data
- Genome-wide maps of nuclear lamina interactions in single human cells
- Mechanisms and Consequences of Cancer Genome Instability: Lessons from Genome Sequencing Studies.
- The genome-wide molecular signature of transcription factors in leukemia.
- Connecting the genome: dynamics and stochasticity in a new hierarchy for chromosome conformation
- Efficient estimation of contact probabilities from inter-bead distance distributions in simulated polymer chains
- Chromatin Landscapes of Retroviral and Transposon Integration Profiles
- THE GENOME IN 3D: A NEW FRONTIER IN HUMAN BRAIN RESEARCH
- Quantitative analysis of genomic element interactions by molecular colony technique
- Investigation of the spatial genome organization of mouse sperm and fibroblasts by the Hi-C method
Related papers
- Methods for the Differential Analysis of Hi-C Data.
- HiCAR: a robust and sensitive multi-omic co-assay for simultaneous measurement of transcriptome, chromatin accessibility, and cis-regulatory chromatin contacts
- Characterization of hundreds of regulatory landscapes in developing limbs reveals two regimes of chromatin folding
- 3C-based methods to detect long-range chromatin interactions
- HiCAR is a robust and sensitive method to analyze open chromatin associated genome organization
- Chromatin globules: a common motif of higher - order chromosome structure?
- Mapping nucleosome-resolution chromatin organization and enhancer-promoter loops in plants using Micro-C-XL
- ChIA-PET analysis of transcriptional chromatin interactions.
- Reconstruction of Three-Dimensional Structures of Chromatin and Its Biological Implications
- Chromatin structure and 3D architecture define differential functions of PU.1 cis regulatory elements in human blood cell lineages