Chromatin Landscapes of Retroviral and Transposon Integration Profiles
Explore this paper's citation graph
Summary
Very large datasets are generated consisting of to unselected integrations in the mouse genome for the Sleeping Beauty and piggyBac transposons, and the Mouse Mammary Tumor Virus, and a model where target site selection is directed at multiple scales is presented.
- Type
- article
- Published
- 2014-04-01
- Cited by
- 88
- References
- 103
- Access
- Open access
- OpenAlex
- https://openalex.org/W1977482508
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:18833512
Keywords
Biology, Insertional mutagenesis, Transposable element, Genetics, Genome
References
- High-throughput retroviral tagging to identify components of specific signaling pathways in cancer
- Structure-based prediction of insertion-site preferences of transposons into chromosomes
- Insertional oncogenesis in 4 patients after retrovirus-mediated gene therapy of SCID-X1.
- Transcription Start Regions in the Human Genome Are Favored Targets for MLV Integration
- Ebola virus entry requires the host‐programmed recognition of an intracellular receptor
- Jarid1b targets genes regulating development and is involved in neural differentiation
- Distinct regulatory mechanisms and functions of p53-activated and p53-repressed DNA damage response genes in embryonic stem cells
- Retroviral insertional mutagenesis: past, present and future
- Tbx3 improves the germ-line competency of induced pluripotent stem cells
- Genomic Prevalence of Heterochromatic H3K9me2 and Transcription Do Not Discriminate Pluripotent from Terminally Differentiated Cells
- Redefining the common insertion site.
- Harnessing transposons for cancer gene discovery
- Comparative epigenomic annotation of regulatory DNA
- Histone H3K27ac separates active from poised enhancers and predicts developmental state
- Control of Embryonic Stem Cell Lineage Commitment by Core Promoter Factor, TAF3
- Molecular maps of the reorganization of genome – nuclear lamina interactions during differentiation
- MMTV insertional mutagenesis identifies genes, gene families and pathways involved in mammary cancer
- Emerging potential of transposons for gene therapy and generation of induced pluripotent stem cells.
- PiggyBac Transposon Mutagenesis: A Tool for Cancer Gene Discovery in Mice
- An embryonic stem cell chromatin remodeling complex, esBAF, is an essential component of the core pluripotency transcriptional network
Cited by
- Human SETMAR is a DNA sequence-specific histone-methylase with a broad effect on the transcriptome
- Recombinant AAV-mediated Gene Therapy Approaches to Treat Progressive Familial Intrahepatic Cholestasis Type 3
- TRIP through the chromatin: a high throughput exploration of enhancer regulatory landscapes.
- Use of DNA transposons for functional genetic screens in mouse models of cancer.
- Sleeping Beauty Transposition
- Chemical profiling of the genome with anti-cancer drugs defines target specificities.
- A Hybrid Adenoviral Vector System Achieves Efficient Long-Term Gene Expression in the Liver via piggyBac Transposition
- Sites of Retroviral DNA Integration: From Basic Research to Clinical Applications
- Sequencing methods and datasets to improve functional interpretation of sleeping beauty mutagenesis screens
- Modeling correction of severe urea cycle defects in the growing murine liver using a hybrid recombinant adeno‐associated virus/piggyBac transposase gene delivery system
- Genetic Engineering of Mesenchymal Stem Cells for Regenerative Medicine
- Applications of DNA integrating elements: Facing the bias bully
- Hybrid nonviral/viral vector systems for improved piggyBac DNA transposon in vivo delivery.
- 3D hotspots of recurrent retroviral insertions reveal long-range interactions with cancer genes
- Genomic Analysis of Sleeping Beauty Transposon Integration in Human Somatic Cells
- Key determinants of target DNA recognition by retroviral intasomes
- The utility of transposon mutagenesis for cancer studies in the era of genome editing
- Meta-Analysis of DNA Tumor-Viral Integration Site Selection Indicates a Role for Repeats, Gene Expression and Epigenetics
- 3D genome organization in health and disease: emerging opportunities in cancer translational medicine
- Dr.VIS v2.0: an updated database of human disease-related viral integration sites in the era of high-throughput deep sequencing
Related papers
- Mechanisms regulating the copy numbers of six LTR retrotransposons in the genome of Drosophila melanogaster
- Transposon vectors for gene‐trap insertional mutagenesis in vertebrates
- Transposon insertional mutagenesis in rice.
- Enhancer and Gene Trap Transposon Mutagenesis in Arabidopsis
- Insertional versus targeted mutagenesis in mice.
- Transposon insertional mutagenesis in rice.
- PiggyBac Transposon for Mammalian Applications
- Mutagenesis by retroviral insertion in chemical mutagen-generated quasi-haploid mammalian cells.