The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity.
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Summary
A hypothalamus-specific mRNA is described that encodes preprohypocretin, the putative precursor of a pair of peptides that share substantial amino acid identities with the gut hormone secretin, suggesting that the hypocretins function within the CNS as neurotransmitters.
- Type
- article
- Published
- 1998-01-06
- Cited by
- 3,826
- References
- 57
- Access
- Open access
- OpenAlex
- https://openalex.org/W2152211310
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:8187084
Keywords
Hypothalamus, Orexin, Brainstem, Neuropeptide, Hippocampal formation
References
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Cited by
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- Narcolepsy and the HLA region.
- Orexin A reverses propofol and thiopental induced cytoskeletal rearrangement in rat neurons.
- Orexins (hypocretins) directly excite tuberomammillary neurons
- Interaction of the hypocretins with neurotransmitters in the nucleus accumbens.
- Hypocretin (orexin) enhances neuron activity and cell synchrony in developing mouse GFP‐expressing locus coeruleus
- Induction of active (REM) sleep and motor inhibition by hypocretin in the nucleus pontis oralis of the cat.
- Orexins and their receptors: structural aspects and role in peripheral tissues
- Roles of orexins in the regulation of feeding and arousal.
- Neuropeptides and anticipatory changes in behaviour and physiology: seasonal body weight regulation in the Siberian hamster.
- Expression of hypothalamic neuropeptides after acute TCDD treatment and distribution of Ah receptor repressor.
- Hypocretinergic Control of Spinal Cord Motoneurons
- Variants of the orexin2/hcrt2 receptor gene identified in patients with excessive daytime sleepiness and patients with Tourette's syndrome comorbidity
- Prepro-orexin mRNA expression in the rat brain is increased during pregnancy.
- Central orexin sensitivity, physical activity, and obesity in diet-induced obese and diet-resistant rats.
- Integration of feeding and spontaneous physical activity: role for orexin.
- Orexin-induced apoptosis: the key role of the seven-transmembrane domain orexin type 2 receptor.
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