Cell and molecular biology of the incretin hormones glucagon-like peptide-I and glucose-dependent insulin releasing polypeptide.
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Summary
The connection between the gastrointestinal tract and the endocrine pancreas was shown in the 1960s when insulin became measurable in plasma and the insulin response to oral glucose and intravenous glucose, resulting in neaemia, was shown.
- Type
- review
- Published
- 1995-06-01
- Cited by
- 574
- References
- 236
- OpenAlex
- https://openalex.org/W2016147073
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:21115167
Keywords
Incretin, Secretin, Internal medicine, Endocrinology, Insulin
References
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- The effects of gastric inhibitory polypeptide (GIP) on the release of anterior pituitary hormones.
- Glucagon-like peptide-1 and glucose-dependent insulin-releasing polypeptide plasma levels in response to nutrients.
- Glucose-dependent alterations of intracellular free calcium by glucagon-like peptide-1(7-36amide) in individual ob/ob mouse beta-cells.
- The Action of Intestinal Extracts
- Effect of proglucagon-derived peptides on amylase release from rat pancreatic acini
- Early O‐glycosidic glycosylation of proglucagon in pancreatic islets: an unusual type of prohormonal modification.
- Nucleotide sequence determination of chicken glucagon precursor cDNA
- Isolation and characterization of exendin-4, an exendin-3 analogue, from Heloderma suspectum venom. Further evidence for an exendin receptor on dispersed acini from guinea pig pancreas.
- Complete sequences of glucagon-like peptide-1 from human and pig small intestine.
- A pancreatic islet cell-specific enhancer-like element in the glucagon gene contains two domains binding distinct cellular proteins.
- Glucagon gene expression in vertebrate brain.
- Both amidated and nonamidated forms of glucagon-like peptide I are synthesized in the rat intestine and the pancreas.
- Ileal proglucagon gene expression in the rat: characterization in intestinal adaptation using in situ hybridization.
- Functional characterization of a cAMP-responsive element of the rat insulin I gene.
- Structure-activity studies of glucagon-like peptide-1.
- Proglucagon processing in porcine and human pancreas.
- GLP-1 stimulates secretion of macromolecules from airways and relaxes pulmonary artery.
Cited by
- Aspects of novel sites of regulation of the insulin stimulus-secretion coupling in normal and diabetic pancreatic islets
- Uncoupling protein 2 negatively regulates glucose-induced glucagon-like peptide 1 secretion.
- The regulation of function, growth and survival of GLP-1-producing L-cells.
- Genetic variations in TCF7L2 influence therapeutic response to sulfonylureas in Indian diabetics.
- Targeting type 2 diabetes.
- Glucagon-like peptide-1 and diabetes treatment
- The role of incretin on diabetes mellitus.
- Using the lymph fistula rat model to study incretin secretion.
- Defining genotype-phenotype correlations in children with congenital hyperinsulinism
- The association of DNA methylation patterns in TCF7L2 and GIPR genes with Type 2 Diabetes
- Pathogenese des Diabetes mellitus und diabetischer Spätkomplikationen
- The novel roles of glucagon-like peptide-1, angiotensin II, and vitamin D in islet function.
- Effects of Acute Nutrient Stimulation and Chronic High-Fat Feeding on GIP and GLP-1 Secretion in the Lymph Fistula Rat
- GLP-1 REGULATES PROLIFERATION OF GLP-1 SECRETING CELLS THROUGH A FEEDBACK MECHANISM
- Gastric Inhibitory Polypeptide Analogues
- Incretin hormones and beta cell function in chronic pancreatitis.
- Le incretine nella terapia del diabete di tipo 2
- Regulation of insulin signaling and its developmental and functional roles on peptidergic neurons in the Drosophila central nervous system
- Molecular Basis of Pancreas Development and Function
- Hormonal and Nutrient Signalling to Protein Kinase B and Mammalian Target of Rapamycin in Pancreatic Beta-Cells
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