Bacterial Persistence as a Phenotypic Switch
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Summary
Investigating the persistence of single cells of Escherichia coli with the use of microfluidic devices found phenotypic switching occurred between normally growing cells and persister cells having reduced growth rates, leading to a simple mathematical description of the persistence switch.
- Type
- article
- Published
- 2004-09-10
- Cited by
- 2,948
- References
- 18
- OpenAlex
- https://openalex.org/W2148323109
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:39698842
Keywords
Persistence (discontinuity), Biology, Multidrug tolerance, Phenotype, Homogeneous
References
- hipA, a newly recognized gene of Escherichia coli K-12 that affects frequency of persistence after inhibition of murein synthesis
- Persister cells and tolerance to antimicrobials.
- TREATMENT OF STAPHYLOCOCCAL INFECTIONS WITH PENICILLIN BY INTERMITTENT STERILISATION
- Evaluation of the bactericidal activity of beta-lactam antibiotics on slowly growing bacteria cultured in the chemostat
- Pseudomonas biofilm formation and antibiotic resistance are linked to phenotypic variation
- Phenotypic switching of antibiotic resistance circumvents permanent costs in Staphylococcus aureus.
- Programmed Cell Death in Escherichia coli: Some Antibiotics Can Trigger mazEFLethality
- Bet hedging and the diapause strategies of the cricket Allonemobius fasciatus
- Monolithic microfabricated valves and pumps by multilayer soft lithography.
- Stimulation of the multiplication of Micrococcus luteus by an autocrine growth factor
- Fabrication of microfluidic systems in poly(dimethylsiloxane)
- Tuberculosis: a problem with persistence
- Mutants of Escherichia coli K-12 exhibiting reduced killing by both quinolone and beta-lactam antimicrobial agents
- Characterization of the hipA7 allele of Escherichia coli and evidence that high persistence is governed by (p)ppGpp synthesis
- Force and focal adhesion assembly: a close relationship studied using elastic micropatterned substrates
- Conditional impairment of cell division and altered lethality in hipA mutants of Escherichia coli K-12
- Soft lithography in biology and biochemistry.
- Programmed Death in Bacteria
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- Systems biology and its impact on anti-infective drug development.
- Review of biologically active filters in drinking water applications
- Phosphatases modulate the bistable sporulation gene expression pattern in Bacillus subtilis
- Positive-feedback loops as a flexible biological module.
- Does Dormancy Increase Fitness of Bacterial Populations in Time-Varying Environments?
- Functional roles for noise in genetic circuits
- The origins of cancer robustness and evolvability.
- Systems biology of stem cells: three useful perspectives to help overcome the paradigm of linear pathways
- Central dogma at the single-molecule level in living cells
- Phenotypic plasticity stimulated by cooperation fosters pattern diversity of bacterial colonies.
- Programmed Heterogeneity: Epigenetic Mechanisms in Bacteria
- c-di-GMP heterogeneity is generated by the chemotaxis machinery to regulate flagellar motility
- The Fatty Acid Signaling Molecule cis-2-Decenoic Acid Increases Metabolic Activity and Reverts Persister Cells to an Antimicrobial-Susceptible State
- A master equation and moment approach for biochemical systems with creation-time-dependent bimolecular rate functions.
- ComGA-RelA interaction and persistence in the Bacillus subtilis K-State
- The Alternative Sigma Factor SigX Controls Bacteriocin Synthesis and Competence, the Two Quorum Sensing Regulated Traits in Streptococcus mutans
- Antibiotic Resistance Pattern and Distribution of pslA Gene Among Biofilm Producing Pseudomonas aeruginosa Isolated From Waste Water of a Burn Center
- Constraints, Trade-offs and the Currency of Fitness
- Virulence of Acinetobacter baumannii Exhibiting Phenotypic Heterogeneous Growth against Meropenem in a Murine Thigh Infection Model
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