Virulence of Acinetobacter baumannii Exhibiting Phenotypic Heterogeneous Growth against Meropenem in a Murine Thigh Infection Model
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Summary
In vitro meropenem exposure induces phenotypic heterogeneous growth in A. baumannii and the heterogeneously grown subpopulations exhibited lower virulence, killing fewer mice and responding equally to mer Openem treatment, despite their higher MICs.
- Type
- article
- Published
- 2013-03-01
- Cited by
- 6
- References
- 29
- Access
- Open access
- OpenAlex
- https://openalex.org/W27029293
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:13227418
Keywords
Catalysis, NOx, Selective catalytic reduction, Waste management, Environmental science
References
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- The cost of resistance to colistin in Acinetobacter baumannii: a proteomic perspective
- Prevalence and analysis of microbiological factors associated with phenotypic heterogeneous resistance to carbapenems in Acinetobacter baumannii.
- Novel Acquired Metallo-β-Lactamase Gene, blaSIM-1, in a Class 1 Integron from Acinetobacter baumannii Clinical Isolates from Korea
- Phenotypic Tolerance: Antibiotic Enrichment of Noninherited Resistance in Bacterial Populations
- Heteroresistance to Meropenem in Carbapenem-Susceptible Acinetobacter baumannii
- In vivo efficacy and pharmacokinetics of tomopenem (CS-023), a novel carbapenem, against Pseudomonas aeruginosa in a murine chronic respiratory tract infection model.
- fAUC/MIC is the most predictive pharmacokinetic/pharmacodynamic index of colistin against Acinetobacter baumannii in murine thigh and lung infection models.
- Heteroresistance to carbapenems in Acinetobacter baumannii.
- Efficacy of telavancin in a murine model of pneumonia induced by methicillin-susceptible Staphylococcus aureus.
- Imipenem heteroresistance induced by imipenem in multidrug-resistant Acinetobacter baumannii: mechanism and clinical implications.
- Outbreak of Infection by Carbapenem-Resistant Acinetobacter baumannii Producing the Carbapenemase OXA-58 in Belgium
- In Vivo Activities of Amoxicillin and Amoxicillin-Clavulanate against Streptococcus pneumoniae: Application to Breakpoint Determinations
- In vitro and in vivo activity of meropenem and sulbactam against a multidrug-resistant Acinetobacter baumannii strain.
- Bacterial Persistence as a Phenotypic Switch
- Overview of nosocomial infections caused by gram-negative bacilli.
- Mechanisms of multidrug resistance in Acinetobacter species and Pseudomonas aeruginosa.
Cited by
- Étude de la virulence d’Acinetobacter baumannii dans un modèle d’infection expérimental du tractus urinaire
- Формирование персистеров у клинических изолятов K.pneumoniae , индуцированных меропенемом, амикацином и их комбинацией
- Mechanisms Protecting Acinetobacter baumannii against Multiple Stresses Triggered by the Host Immune Response, Antibiotics and Outside-Host Environment
- In vivo fitness of carbapenem-resistant Acinetobacter baumannii (CRAB) strains in murine infection is associated with treatment failure in human infections.
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