Increased tumor necrosis factor-α, cleaved caspase 3 levels and insulin receptor substrate-1 phosphorylation in the β1-adrenergic receptor knockout mouse
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Summary
These studies further support the idea that maintenance of β1-adrenergic receptor signaling is beneficial for retinal homeostasis and support that novel β-adRenergic receptor agents may provide additional avenues for therapeutics.
- Type
- article
- Published
- 2011-07-06
- Cited by
- 22
- References
- 35
- Access
- Open access
- OpenAlex
- https://openalex.org/W2148149909
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:7718555
Keywords
Insulin receptor, Endocrinology, Internal medicine, Biology, Receptor
References
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- Abnormalities of retinal metabolism in diabetes and experimental galactosemia. VII. Effect of long-term administration of antioxidants on the development of retinopathy.
- Insulin and β-adrenergic Receptors Inhibit Retinal Endothelial Cell Apoptosis Through Independent Pathways
- IGFBP3 suppresses retinopathy through suppression of oxygen-induced vessel loss and promotion of vascular regrowth
- Increased basement membrane thickness, pericyte ghosts, and loss of retinal thickness and cells in dopamine beta hydroxylase knockout mice.
- Effects of Insulin-Like Growth Factor-1 (IGF-1) Receptor Signaling on Rates of Apoptosis in Retina of Dopamine Beta Hydroxlyase (Dbh-/-) Knockout Mice
- Targeted disruption of the mouse beta1-adrenergic receptor gene: developmental and cardiovascular effects.
- Therapies for hyperglycaemia-induced diabetic complications: from animal models to clinical trials
- Insulin-Like Growth Factor Binding Protein-3 Mediates Vascular Repair by Enhancing Nitric Oxide Generation
- Maintenance of beta-adrenergic receptor signaling can reduce Fas signaling in human retinal endothelial cells.
- Insulin resistance induced by tumor necrosis factor-alpha in myocytes and brown adipocytes.
- Sympathetic innervation regulates basement membrane thickening and pericyte number in rat retina.
- Insulin-Like Growth Factor Binding Proteins: New Proteins, New Functions
- Regulation of insulin-like growth factor-I receptor gene expression by tumor necrosis factor-alpha and interferon-gamma.
- Accelerated death of retinal microvascular cells in human and experimental diabetic retinopathy.
Cited by
- β1-adrenergic receptor stimulation by agonist Compound 49b restores insulin receptor signal transduction in vivo
- β-adrenergic receptor-dependent and -independent effects of propranolol in infantile hemangioma
- Insulin-like growth factor binding protein-3 inhibits monocyte adhesion to retinal endothelial cells in high glucose conditions
- Sympathetic nerves: How do they affect angiogenesis, particularly during wound healing of soft tissues?
- Intravitreal Injection of IGFBP-3 Restores Normal Insulin Signaling in Diabetic Rat Retina
- TNFα Inhibits IGFBP-3 through Activation of p38α and Casein Kinase 2 in Human Retinal Endothelial Cells
- Propranolol inhibits growth of hemangioma-initiating cells but does not induce apoptosis
- β2-Adrenergic Receptor Knockout Mice Exhibit A Diabetic Retinopathy Phenotype
- Targeting tumor necrosis factor alpha (TNF-α) in diabetic rats could approve avenues for an efficient strategy for diabetic therapy.
- Attenuation of Choroidal Neovascularization by β2-Adrenergic Receptor Antagonism
- Protective effects of β1/2 adrenergic receptor deletion in a model of oxygen-induced retinopathy.
- IGFBP-3 and TNF-α regulate retinal endothelial cell apoptosis.
- The β-adrenergic system as a possible new target for pharmacologic treatment of neovascular retinal diseases.
- Etanercept restores normal insulin signal transduction in β2-adrenergic receptor knockout mice
- Role of β-adrenergic receptor regulation of TNF-α and insulin signaling in retinal Muller cells.
- β2–Adrenergic Receptor Antagonism Attenuates CNV Through Inhibition of VEGF and IL-6 Expression
- A regulatory role for β-adrenergic receptors regarding the resolvin D1 (RvD1) pathway in the diabetic retina
- Inflammation In The Pathogenesis Of Diabetic Retinopathy
- Sympathetic Effects of Internal Carotid Nerve Manipulation on Choroidal Vascularity and Related Measures.
- Effect of Galohgor Cookies Intake by Postpartum Mother on Newborn’s Growth
Related papers
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- Compound 49b prevents diabetes-induced apoptosis through increased IGFBP-3 levels.
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- Sympathetic innervation regulates basement membrane thickening and pericyte number in rat retina.
- Increased basement membrane thickness, pericyte ghosts, and loss of retinal thickness and cells in dopamine beta hydroxylase knockout mice.
- β2-Adrenergic Receptor Knockout Mice Exhibit A Diabetic Retinopathy Phenotype
- Role of β-adrenergic receptor regulation of TNF-α and insulin signaling in retinal Muller cells.
- TNFα and SOCS3 regulate IRS-1 to increase retinal endothelial cell apoptosis