Insulin-like growth factor binding protein-3 mediates cytokine-induced mesangial cell apoptosis.
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Summary
A novel mechanism for TNF-alpha-induced mesangial cell apoptosis mediated by IGFBP-3 is supported and regulation of pThr308 activity as a novel mechanism underlying IGF BP-3 action is presented.
- Type
- article
- Published
- 2005-06-01
- Cited by
- 43
- References
- 43
- Access
- Open access
- OpenAlex
- https://openalex.org/W1986170576
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:25210629
Keywords
Mesangial cell, Apoptosis, Insulin-like growth factor-binding protein, Internal medicine, Endocrinology
References
- Insulin‐Like Growth Factor‐1
- Tyrosine kinase cell signaling pathways of rat mesangial cells in 3-dimensional cultures: response to fetal bovine serum and platelet-derived growth factor-BB.
- Insulin-like Growth Factor-binding Protein-3 Potentiates Epidermal Growth Factor Action in MCF-10A Mammary Epithelial Cells
- Usefulness of a Highly Sensitive Urinary and Serum IL-6 Assay in Patients with Diabetic Nephropathy
- Inflammation and pathogenesis of diabetic nephropathy.
- Insulin-like growth factor-1, growth hormone-dependent insulin-like growth factor-binding protein and growth in children with chronic renal failure
- Evaluation of the components of insulin‐like growth factor (IGF)‐IGF binding protein (IGFBP) system in adolescents with type 1 diabetes and persistent microalbuminuria: relationship with increased urinary excretion of IGFBP‐3 18 kD N‐terminal fragment
- Inflammatory parameters are independently associated with urinary albumin in type 2 diabetes mellitus.
- Normalization of Plasma Lipid Peroxides, Monocyte Adhesion, and Tumor Necrosis Factor-α Production in NIDDM Patients After Gliclazide Treatment
- Bioactivity of a 29-Kilodalton Insulin-Like Growth Factor Binding Protein-3 Fragment Present in Excess in Chronic Renal Failure Serum
- Characterization of Insulin-Like Growth Factor Binding Protein-3 in Chronic Renal Failure Serum
- Rapid insulin-like growth factor (IGF)-independent effects of IGF binding protein-3 on endothelial cell survival.
- Gene expression of the insulin-like growth factor system during mouse kidney development.
- Growth hormone resistance and inhibition of somatomedin activity by excess of insulin-like growth factor binding protein in uraemia
- The Insulin-like Growth Factor Axis in Pediatrics
- Elevated levels of interleukin-18 and tumor necrosis factor-alpha in serum of patients with type 2 diabetes mellitus: relationship with diabetic nephropathy.
- Expression of insulin-like growth factor and binding protein genes during nephrogenesis.
- Urinary tumor necrosis factor contributes to sodium retention and renal hypertrophy during diabetes.
- Localization of mRNAs for insulin-like growth factor binding proteins 1 to 6 in rat kidney.
- Characterization of insulin-like growth factor binding proteins and regulation of IGFBP3 in human mesangial cells.
Cited by
- Interactions between IGFBP-3 and Nuclear Receptors in Prostate Cancer Apoptosis
- The effect of pentoxifylline on reduction of proteinuria among patients with type 2 diabetes under blockade of angiotensin system: a double blind and randomized clinical trial.
- The insulin-like growth factor system in chronic kidney disease: Pathophysiology and therapeutic opportunities
- Regulation of apoptosis by insulin-like growth factor (IGF)-I.
- Activation of various downstream signaling molecules by IGFBP-3
- Role of Growth Factors in Diabetic Kidney Disease
- Tumor necrosis factor-alpha as a therapeutic target for diabetic nephropathy.
- Insulin-like growth factor-binding protein-3 mediates high glucose-induced apoptosis by increasing oxidative stress in proximal tubular epithelial cells.
- Nonsecreted Insulin-like Growth Factor Binding Protein-3 (IGFBP-3) Can Induce Apoptosis in Human Prostate Cancer Cells by IGF-independent Mechanisms without Being Concentrated in the Nucleus*
- Compound 49b prevents diabetes-induced apoptosis through increased IGFBP-3 levels.
- Novel roles of the IGF-IGFBP axis in etiopathophysiology of diabetic nephropathy.
- Role of growth hormone, insulin-like growth factor 1 and insulin-like growth factor-binding protein 3 in development of non-alcoholic fatty liver disease
- Elevated IGFBP3 levels in diabetic tears: a negative regulator of IGF-1 signaling in the corneal epithelium
- Growth hormone, insulin-like growth factor-1, and the kidney: pathophysiological and clinical implications.
- Novel actions of IGFBP-3 on intracellular signaling pathways of insulin-secreting cells.
- IGFBP-3 and TNF-α regulate retinal endothelial cell apoptosis.
- Wnt/beta-catenin signaling modulates survival of high glucose-stressed mesangial cells.
- VEGF-A and Serum Withdrawal Induced Changes in the Transcript Profile in Human Endometrial Endothelial Cells
- Endogenous IGFBP‐3 is required for both growth factor‐stimulated cell proliferation and cytokine‐induced apoptosis in mammary epithelial cells
- An N-terminal fragment of insulin-like growth factor binding protein-3 (IGFBP-3) induces apoptosis in human prostate cancer cells in an IGF-independent manner.
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