Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity
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Summary
Substantial insight is provided into the intricate mechanisms of bacterial regulation of the cross-talk between the host and gut microbiota and provides a rationale for the development of a treatment that uses this human mucus colonizer for the prevention or treatment of obesity and its associated metabolic disorders.
- Type
- article
- Published
- 2013-05-13
- Cited by
- 4,191
- References
- 40
- Access
- Open access
- OpenAlex
- https://openalex.org/W2147790901
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:7207349
Keywords
Akkermansia muciniphila, Biology, Gut flora, Inflammation, Type 2 diabetes
References
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- The habitat, double life, citizenship, and forgetfulness of IgA
- Distinct composition of gut microbiota during pregnancy in overweight and normal-weight women.
- Regulation of induced colonic inflammation by Lactobacillus acidophilus deficient in lipoteichoic acid
- The cellular and signaling networks linking the immune system and metabolism in disease
- The two mucus layers of colon are organized by the MUC2 mucin, whereas the outer layer is a legislator of host–microbial interactions
- Altered Gut Microbiota and Endocannabinoid System Tone in Obese and Diabetic Leptin-Resistant Mice: Impact on Apelin Regulation in Adipose Tissue
- Immune adaptations that maintain homeostasis with the intestinal microbiota
- Gut microbiota composition is associated with body weight, weight gain and biochemical parameters in pregnant women
- Microbes inside—from diversity to function: the case of Akkermansia
- Paneth cells, antimicrobial peptides and maintenance of intestinal homeostasis
- Diet-induced obesity is linked to marked but reversible alterations in the mouse distal gut microbiome.
- Innate immune signalling at the intestinal epithelium in homeostasis and disease
- Selective increases of bifidobacteria in gut microflora improve high-fat-diet-induced diabetes in mice through a mechanism associated with endotoxaemia
- 2-Oleoyl glycerol is a GPR119 agonist and signals GLP-1 release in humans.
- The Antibacterial Lectin RegIII-Gamma Promotes the Spatial Segregation of Microbiota and Host in the Intestine
- The Genome of Akkermansia muciniphila, a Dedicated Intestinal Mucin Degrader, and Its Use in Exploring Intestinal Metagenomes
- Early life treatment with vancomycin propagates Akkermansia muciniphila and reduces diabetes incidence in the NOD mouse
- A metagenome-wide association study of gut microbiota in type 2 diabetes
Cited by
- Classical endocannabinoid‐like compounds and their regulation by nutrients
- Symbiosis as the way of eukaryotic life: The dependent co-origination of the body
- Epithelial Cell Shedding and Barrier Function
- Probiotics and immunity: provisional role for personalized diets and disease prevention
- Disparate Metabolic Responses in Mice Fed a High-Fat Diet Supplemented with Maize-Derived Non-Digestible Feruloylated Oligo- and Polysaccharides Are Linked to Changes in the Gut Microbiota
- Strain-level microbial epidemiology and population genomics from shotgun metagenomics
- Association of Early-Life Antibiotic Use and Protective Effects of Breastfeeding: Role of the Intestinal Microbiota.
- Mango Supplementation Modulates Gut Microbial Dysbiosis and Short-Chain Fatty Acid Production Independent of Body Weight Reduction in C57BL/6 Mice Fed a High-Fat Diet.
- Metformin alters the gut microbiome of individuals with treatment-naive type 2 diabetes, contributing to the therapeutic effects of the drug
- Bugs, guts and brains, and the regulation of food intake and body weight.
- Layered defense: how mucus and tight junctions seal the intestinal barrier
- Segment-specific responses of intestinal epithelium transcriptome to in-feed antibiotics in pigs.
- Gut microbiota and probiotics intervention: A potential therapeutic target for management of cardiometabolic disorders and chronic kidney disease?
- Influence of diet and dietary nanoparticles on gut dysbiosis.
- Bilophila wadsworthia aggravates high fat diet induced metabolic dysfunctions in mice
- Liraglutide modulates gut microbiota and reduces NAFLD in obese mice.
- Green tea extract prevents obesity in male mice by alleviating gut dysbiosis in association with improved intestinal barrier function that limits endotoxin translocation and adipose inflammation.
- Host-Microbe Interplay in the Cardiometabolic Benefits of Dietary Polyphenols.
- Microbiota, inflammation and obesity.
- Increased Body Weight in Adulthood Following a Peripubertal Stressor and Proposed Mechanism for Effects of Increased Adiposity on Estrogen-dependent Behaviors
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