Amino acid substitution matrices from protein blocks.

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Summary

This work has derived substitution matrices from about 2000 blocks of aligned sequence segments characterizing more than 500 groups of related proteins, leading to marked improvements in alignments and in searches using queries from each of the groups.

Type
article
Published
1992-11-15
Cited by
6,487
References
34
Access
Open access

Keywords

Substitution (logic), Amino acid substitution, Amino acid, Computational biology, Similarity (geometry)

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