Amino acid substitution matrices from protein blocks.
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Summary
This work has derived substitution matrices from about 2000 blocks of aligned sequence segments characterizing more than 500 groups of related proteins, leading to marked improvements in alignments and in searches using queries from each of the groups.
- Type
- article
- Published
- 1992-11-15
- Cited by
- 6,487
- References
- 34
- Access
- Open access
- OpenAlex
- https://openalex.org/W2143210482
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:13389189
Keywords
Substitution (logic), Amino acid substitution, Amino acid, Computational biology, Similarity (geometry)
References
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- Comparative model-building of the mammalian serine proteases.
- Multiple sequence alignment with hierarchical clustering.
- The SWISS-PROT protein sequence data bank.
- Basic local alignment search tool.
- Identification of common molecular subsequences.
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- Self‐organizing hierarchic networks for pattern recognition in protein sequence
- On Near-Optimal Alignments of Biological Sequences
- A survey of homeobox genes in Chaetopterus variopedatus and analysis of polychaete homeodomains.
- Cloning, Yeast Expression, and Characterization of the Coupling of Two Distantly Related Arabidopsis thalianaNADPH-Cytochrome P450 Reductases with P450 CYP73A5*
- Empirical statistical estimates for sequence similarity searches.
- Use of the phage display technique for detection of epitopes recognized by polyclonal rabbit gliadin antibodies
- The Root of the Universal Tree of Life Inferred from Anciently Duplicated Genes Encoding Components of the Protein-Targeting Machinery
- Family pairwise search with embedded motif models
- Characterization of single-nucleotide polymorphisms in coding regions of human genes
- Automated Genome-Wide Protein Domain Exploration
- PAC: Progressive Alignment with Consensus Sequences
- A method for the improvement of threading‐based protein models
- Gene Cloning and Nucleotide Sequencing and Properties of a Cocaine Esterase from Rhodococcus sp. Strain MB1
- Gene structure prediction by spliced alignment of genomic DNA with protein sequences: increased accuracy by differential splice site scoring.
- Darwin v. 2.0: an interpreted computer language for the biosciences
- Searching sequence databases via de novo peptide sequencing by tandem mass spectrometry.
- A simple genetic algorithm for multiple sequence alignment.
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