Elucidation of a universal size-control mechanism in Drosophila and mammals.
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Summary
It is demonstrated that a single phosphorylation site in Yki mediates the growth-suppressive output of the Hippo pathway, and that its dysregulation leads to tumorigenesis, uncovering a universal size-control mechanism in metazoan.
- Type
- article
- Published
- 2007-09-21
- Cited by
- 2,407
- References
- 40
- Access
- Open access
- OpenAlex
- https://openalex.org/W2141595533
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:14967252
Keywords
Hippo signaling pathway, Biology, Phosphorylation, Cell biology, Signal transduction
References
- Yes-associated protein (YAP65) is a proline-rich phosphoprotein that binds to the SH3 domain of the Yes proto-oncogene product.
- p73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumours
- Mice deficient of Lats1 develop soft-tissue sarcomas, ovarian tumours and pituitary dysfunction
- Cell-autonomous regulation of cell and organ growth in Drosophila by Akt/PKB
- Human homologue of the Drosophila melanogaster lats tumour suppressor modulates CDC2 activity
- Yes-associated Protein and p53-binding Protein-2 Interact through Their WW and SH3 Domains*
- Overexpression of hepatic lipase in transgenic rabbits leads to a marked reduction of plasma high density lipoproteins and intermediate density lipoproteins.
- c-MYC: more than just a matter of life and death
- Notch2-positive progenitors with the intrinsic ability to give rise to pancreatic ductal cells
- Defects in Yolk Sac Vasculogenesis, Chorioallantoic Fusion, and Embryonic Axis Elongation in Mice with Targeted Disruption of Yap65
- Heterogeneous Nuclear Ribonuclear Protein U Associates with YAP and Regulates Its Co-activation of Bax Transcription*
- Drosophila myc regulates cellular growth during development.
- Yes-Associated Protein 65 Localizes P62c-Yes to the Apical Compartment of Airway Epithelia by Association with Ebp50
- A WW domain‐containing Yes‐associated protein (YAP) is a novel transcriptional co‐activator
- LATS1 tumour suppressor affects cytokinesis by inhibiting LIMK1
- From cell structure to transcription: Hippo forges a new path.
- Akt phosphorylates the Yes-associated protein, YAP, to induce interaction with 14-3-3 and attenuation of p73-mediated apoptosis.
- 14-3-3 proteins: regulation of subcellular localization by molecular interference.
- WW Domain-containing Protein YAP Associates with ErbB-4 and Acts as a Co-transcriptional Activator for the Carboxyl-terminal Fragment of ErbB-4 That Translocates to the Nucleus*
- The Protein Kinase Complement of the Human Genome
Cited by
- Adherens junctions and cancer.
- YAP-regulation of dynamic cell behaviour underlying organogenesis
- Efficient Genetic Method for Establishing Drosophila Cell Lines Unlocks the Potential to Create Lines of Specific Genotypes
- A tumor-suppressing mechanism in Drosophila involving cell competition and the Hippo pathway
- KIBRA Regulates Hippo Signaling Activity via Interactions with Large Tumor Suppressor Kinases*
- Screening of binding proteins that interact with human Salvador 1 in a human fetal liver cDNA library by the yeast two-hybrid system
- The Hippo pathway in disease and therapy: cancer and beyond
- A YAP/TAZ-Regulated Molecular Signature is Associated with Oral Squamous Cell Carcinoma
- Size control: the developmental physiology of body and organ size regulation
- Mechanism of action of a WWTR1(TAZ)-CAMTA1 fusion oncoprotein
- Emerging evidence on the role of the Hippo/YAP pathway in liver physiology and cancer
- TAZ and YAP are frequently activated oncoproteins in sarcomas
- The novel YAP target gene, SGK1, upregulates TAZ activity by blocking GSK3β-mediated TAZ destabilization.
- Cultured cells and wing disc size of silkworm can be controlled by the Hippo pathway
- Usp7 regulates Hippo pathway through deubiquitinating the transcriptional coactivator Yorkie
- Increased expression of YAP is associated with decreased cell autophagy in the eutopic endometrial stromal cells of endometriosis.
- High-throughput Human Cell Reprogramming through Substrate and Microfluidics Integration
- Phosphorylation Regulation of T Lymphocyte Migration
- Genetic regulation of autophagic cell death in Drosophila melanogester
- A study of epithelial cell delamination in Drosophila
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