CTLA-4 and PD-1 Receptors Inhibit T-Cell Activation by Distinct Mechanisms
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- Type
- article
- Published
- 2004-11-16
- Cited by
- 1,893
- References
- 76
- Access
- Open access
- OpenAlex
- https://openalex.org/W2140875987
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:27491872
Keywords
Biology, Phosphorylation, Cell biology, CD28, Protein kinase B
References
- Protein Kinase B Regulates T Lymphocyte Survival, Nuclear Factor κb Activation, and Bcl-XL Levels in Vivo
- Site-directed mutagenesis of large (13-kb) plasmids in a single-PCR procedure.
- Haemopoietic cell growth factor mediates cell survival via its action on glucose transport.
- Expression profiling using microarrays fabricated by an ink-jet oligonucleotide synthesizer
- CD150 Association with Either the SH2-Containing Inositol Phosphatase or the SH2-Containing Protein Tyrosine Phosphatase Is Regulated by the Adaptor Protein SH2D1A1
- A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002).
- Cutting Edge: Tyrosine-Independent Transmission of Inhibitory Signals by CTLA-41
- Structural Analysis of CTLA-4 Function In Vivo1
- CTLA-4 ligation delivers a unique signal to resting human CD4 T cells that inhibits interleukin-2 secretion but allows Bcl-X(L) induction.
- Inhibitory effect of a marine-sponge toxin, okadaic acid, on protein phosphatases. Specificity and kinetics.
- Akt provides the CD28 costimulatory signal for up-regulation of IL-2 and IFN-γ but not TH2 cytokines
- Ligation of B7-1/B7-2 by Human CD4+ T Cells Triggers Indoleamine 2,3-Dioxygenase Activity in Dendritic Cells1
- Secondary but not primary T cell responses are enhanced in CTLA‐4‐deficient CD8+ T cells
- Regulation of T Cell Receptor Signaling by Tyrosine Phosphatase SYP Association with CTLA-4
- Activated Akt promotes increased resting T cell size, CD28‐independent T cell growth, and development of autoimmunity and lymphoma
- Ido expression by dendritic cells: tolerance and tryptophan catabolism
- The costimulation-regulated duration of PKB activation controls T cell longevity
- An improved procedure for identifying and quantitating protein phosphatases in mammalian tissues
- Costimulation and autoimmunity.
- Intracellular Signalling: Switching off signals
Cited by
- Estudio del rol de la vía de PD-1 sobre la respuesta inmune de células Nk y de los mecanismos inmunológicos inducidos por las células Th9 frente a la infección por M. tuberculosis
- Modulation of expression of Programmed Death-1 by administration of probiotic Dahi in DMH-induced colorectal carcinogenesis in rats.
- Overexpression of program death‐1 in T cells has mild impact on allograft survival
- Programmed Death-1 antibody blocks therapeutic effects of T-regulatory cells in cockroach antigen-induced allergic asthma.
- Role of the PD-1 Pathway in the Immune Response
- Single Cell Mass Cytometry Analysis of Human Tonsil T Cell Remodeling by Varicella Zoster Virus
- HDAC Inhibition Upregulates PD-1 Ligands in Melanoma and Augments Immunotherapy with PD-1 Blockade
- CTLA-4 and PD-1 Pathways
- PD-1 and its ligands are important immune checkpoints in cancer
- Metabolic Cooperation and Competition in the Tumor Microenvironment: Implications for Therapy
- The role of novel immunotherapies in non-Hodgkin lymphoma
- Overexpression of HHLA2, a member of the B7 family, is associated with worse survival in human colorectal carcinoma
- Antigen-Presenting Cell-Intrinsic PD-1 Neutralizes PD-L1 in cis to Attenuate PD-1 Signaling in T Cells
- Die Lokalisation von PD-1 während des "Kiss of Death"
- Functional studies of candidate genes contributing to type 1 diabetes in the NOD mouse
- Biomarqueurs des états septiques sévères : vers de nouvelles stratégies thérapeutiques individualisées
- The presence of latent virus influences the maintenance and phenotype of the HSV-specific CD8 memory population
- CD28 costimulation in T cells : requirements, outcomes and regulation
- Etude des mécanismes régulateurs des cellules NK : rôle de la molécule PD-1 et de la prostaglandine E2 (PGE2)
- An update on current management of advanced renal cell cancer, biomarkers, and future directions
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