Longitudinal effects of aging on serum total and free testosterone levels in healthy men. Baltimore Longitudinal Study of Aging.
Explore this paper's citation graph
Summary
Observations of health factor independent, age-related longitudinal decreases in T and free T, resulting in a high frequency of hypogonadal values, suggest that further investigation of T replacement in aged men, perhaps targeted to those with the lowest serum T concentrations, are justified.
- Type
- article
- Published
- 2001-02-01
- Cited by
- 2,643
- References
- 66
- Access
- Open access
- OpenAlex
- https://openalex.org/W2139893960
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:19623691
Keywords
Sex hormone-binding globulin, Internal medicine, Endocrinology, Testosterone (patch), Body mass index
References
- Effects of testosterone supplementation in the aging male.
- Testosterone and frailty.
- Textbook of geriatric medicine and gerontology
- Plasma levels of estradiol, testosterone, and DHEAS do not predict risk of coronary artery disease in men.
- Effects of first‐line antihypertensive agents on sexual function and sex hormones
- Endogenous Sex Steroids and Bone Mineral Density in Older Women and Men: The Rancho Bernardo Study
- Effect of age on voluntary force and cross-sectional area of human adductor pollicis muscle.
- Sex hormones and bone mineral density in elderly men.
- Age related changes in free plasma testosterone, dihydrotestosterone and oestradiol.
- Testosterone replacement in older hypogonadal men: a 12-month randomized controlled trial.
- Osteoporosis in men.
- Reproductive hormones in aging men. I. Measurement of sex steroids, basal luteinizing hormone, and Leydig cell response to human chorionic gonadotropin.
- Skeletal aging understanding the functional and structural basis of osteoporosis.
- [The effect of storage and temperature on the analysis of steroids in plasma and blood].
- Osteoporosis in Men: Diagnosis, Pathophysiology, and Prevention
- Plasma free and non-sex-hormone-binding-globulin-bound testosterone are decreased in obese men in proportion to their degree of obesity.
- Spinal osteoporosis in men.
- Comparison of the effects of lung cancer, benign lung disease, and normal aging on pituitary-gonadal function in men.
- HORMONAL STUDIES IN KLINEFELTER'S SYNDROME
- Loss of circadian rhythmicity in blood testosterone levels with aging in normal men.
Cited by
- Bone benefits of testosterone replacement therapy in male hypogonadism.
- Prostate specific antigen predicts the long-term risk of prostate enlargement: results from the Baltimore Longitudinal Study of Aging.
- Consensus Document on substitution therapy with testosterone in hypoandrogenic elderly men
- Testosterone in older men after the Institute of Medicine Report: where do we go from here?
- Testosterone replacement therapy and the risk of prostate cancer. Is there a link?
- Sex hormone ratio changes in men and postmenopausal women with coronary artery disease
- Testosterone treatments: why, when, and how?
- Association of vitamin D status with serum androgen levels in men
- Low testosterone is associated with an increased risk of MACE lethality in subjects with erectile dysfunction.
- Effect of furostanol glycosides from Trigonella foenum‐graecum on the reproductive system of male albino rats
- Bioavailable Testosterone Predicts a Lower Risk of Alzheimer's Disease in Older Men
- Cognitive Decline and Dementia in the Oldest-Old
- The Evaluation and Management of Testosterone Deficiency: the New Frontier in Urology and Men’s Health
- Andropause or male menopause? Rationale for testosterone replacement therapy in older men with low testosterone levels.
- Testosterone lab testing and initiation in the United Kingdom and the United States, 2000 to 2011.
- Diagnosis and Treatment of Low Testosterone among patients with End-Stage Renal Disease
- Relationship between Serum Testosterone and Fracture Risk in Men: A Comparison of RIA and LC-MS/MS.
- Impact of body mass index, age and varicocele on reproductive hormone profile from elderly men
- DHEA, important source of sex steroids in men and even more in women.
- The Potential of Gonadal Hormone Signalling Pathways as Therapeutics for Dementia
Related papers
- Serum levels of sex hormone‐binding globulin (SHBG) are not associated with lower levels of non‐SHBG‐bound testosterone in male newborns and healthy adult men
- Associations of sex-hormone-binding globulin (SHBG) with non-SHBG-bound levels of testosterone and estradiol in independently living men.
- Genesis of breast cancer in Japanese: A possible relationship between sex hormone binding globulin (SHBG) and serum lipid components
- Circulating sex hormone binding globulin (SHBG) and testosterone levels in patients with anorexia nervosa.
- Sex Hormone Binding Globulin as a Reliable Indicator of Hormone Dependence in Human Breast Cancer
- Determination of SHBG-bound sex hormones by selective ammonium sulphate precipitation.
- The analog free testosterone assay: are the results in men clinically useful?
- Effect of ageing on some biophysical parameters amongst males in Benin City, Nigeria
- Androgen levels and sex functions in testosterone-treated hypogonadal men
- The mechanism of androgen uptake and concentration by rat ventral prostate in organ culture.