Testosterone replacement therapy and the risk of prostate cancer. Is there a link?
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Summary
Recommendations are to exclude prostate cancer before initiating TRT in men over age 40 and to closely monitor men in the first year of testosterone replacement, followed by observation in subsequent years.
- Type
- review
- Published
- 2006-07-01
- Cited by
- 32
- References
- 44
- Access
- Open access
- OpenAlex
- https://openalex.org/W2094637672
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:46230482
Keywords
Medicine, Prostate cancer, Testosterone (patch), Libido, Prostate
References
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- Associations of serum testosterone with microvessel density, androgen receptor density and androgen receptor gene polymorphism in prostate cancer.
- Serum sex hormones and measures of benign prostatic hyperplasia
- Long-term biochemical disease-free and cancer-specific survival following anatomic radical retropubic prostatectomy. The 15-year Johns Hopkins experience.
- Serum testosterone--a significant determinant of metastatic relapse for irradiated localized prostate cancer.
- Sex steroid hormone metabolism and prostate cancer.
- Androgen replacement therapy and prostate safety.
- Investigation, treatment and monitoring of late-onset hypogonadism in males. ISA, ISSAM, and EAU recommendations.
- Racial differences in prostate androgen levels in men with clinically localized prostate cancer.
- Long-term testosterone gel (AndroGel) treatment maintains beneficial effects on sexual function and mood, lean and fat mass, and bone mineral density in hypogonadal men.
- Studies on prostatic cancer. I. The effect of castration, of estrogen and androgen injection on serum phosphatases in metastatic carcinoma of the prostate.
- Development and validation of a nomogram predicting the outcome of prostate biopsy based on patient age, digital rectal examination and serum prostate specific antigen.
- Mutation of the androgen receptor causes oncogenic transformation of the prostate.
- Longitudinal PSA changes in men with and without prostate cancer: Assessment of prostate cancer risk
- The Pharmacological Basis of Therapeutics
- Is a digital rectal examination necessary in the diagnosis and clinical staging of early prostate cancer?
- The proliferative function of basal cells in the normal and hyperplastic human prostate
Cited by
- Protective Effects of KH-204 in the Bladder of Androgen-Deprived Rats
- Short term testosterone replacement therapy improves libido and body composition.
- Oxidative stress-related aging: A role for prostate cancer?
- Testosterone therapy in hypogonadal men and potential prostate cancer risk: a systematic review
- Testosterone and the prostate: Implications for the treatment of hypogonadal men
- The Effect of Testosterone Replacement Therapy on Prostate-Specific Antigen (PSA) Levels in Men Being Treated for Hypogonadism
- Changes in prostate specific antigen in hypogonadal men after 12 months of testosterone replacement therapy: support for the prostate saturation theory.
- Pharmacogenetics and pharmacogenomics of sexual dysfunction: current status, gaps and potential applications.
- Does testosterone therapy increase the risk of prostate cancer?
- Testosterone and the Prostate: The Evidence So Far
- Testosterone replacement therapy for late-onset hypogonadism: current trends in Korea.
- Differing levels of testosterone and the prostate: a physiological interplay
- Testosterone replacement therapy and monitoring for the male patients with testosterone deficiency syndrome
- Testosterone replacement therapy
- EFFECTS OF A NEW TESTOSTERONE TRANSDERMAL DELIVERY SYSTEM, BIOLIPID B2®-TESTOSTERONE IN HEALTHY MIDDLE AGED MEN: A CONFOCAL RAMAN SPECTROSCOPY STUDY
- Improvement of andropause symptoms by dandelion and rooibos extract complex CRS-10 in aging male
- Long-term Exposure to Testosterone Therapy and the Risk of High Grade Prostate Cancer.
- Cytotoxicity, cellular localisation and biomolecular interaction of non-covalent metallo-intercalators with appended sex hormone steroid vectors.
- Alternative Digit Ratios and Their Relationship to Prostate Cancer.
- Effect of a Mixed Extract of Fenugreek Seeds and Lespedeza cuneata on Testosterone Deficiency Syndrome
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