Chronic Antidepressant Treatment Increases Neurogenesis in Adult Rat Hippocampus
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Summary
Investigation of the effect of antidepressants on hippocampal neurogenesis in the adult rat using the thymidine analog bromodeoxyuridine (BrdU) as a marker for dividing cells demonstrates that chronic antidepressant treatment significantly increases the number of BrdU-labeled cells in the dentate gyrus and hilus of the hippocampus.
- Type
- article
- Published
- 2000-12-15
- Cited by
- 3,152
- References
- 49
- Access
- Open access
- OpenAlex
- https://openalex.org/W2133565799
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:295906
Keywords
Neurogenesis, Dentate gyrus, Hippocampal formation, Antidepressant, Hippocampus
References
- cAMP Response Element-Mediated Gene Transcription Is Upregulated by Chronic Antidepressant Treatment
- Learning enhances adult neurogenesis in the hippocampal formation
- Chronic Psychosocial Stress Causes Apical Dendritic Atrophy of Hippocampal CA3 Pyramidal Neurons in Subordinate Tree Shrews
- Long-Term Antidepressant Treatments Result in a Tonic Activation of Forebrain 5-HT1A Receptors
- Stress exacerbates neuron loss and cytoskeletal pathology in the hippocampus
- Chronic antidepressant administration increases the expression of cAMP response element binding protein (CREB) in rat hippocampus
- Neural plasticity to stress and antidepressant treatment.
- Glial reduction in the subgenual prefrontal cortex in mood disorders.
- Stress inhibits the proliferation of granule cell precursors in the developing dentate gyrus
- Tianeptine attenuates stress-induced morphological changes in the hippocampus.
- Retinoic acid and neurotrophins collaborate to regulate neurogenesis in adult-derived neural stem cell cultures.
- Why Stress Is Bad for Your Brain
- Adult treatment with haloperidol increases dentate granule cell proliferation in the gerbil hippocampus
- Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus
- EFFECTS OF HALOPERIDOL ON CELL PROLIFERATION IN THE EARLY POSTNATAL RAT BRAIN
- Increased neurogenesis in a model of electroconvulsive therapy.
- A molecular and cellular theory of depression.
- BUdR as an S-phase marker for quantitative studies of cytokinetic behaviour in the murine cerebral ventricular zone
- Hippocampal atrophy in recurrent major depression.
- Running enhances neurogenesis, learning, and long-term potentiation in mice.
Cited by
- Neurogenesis in the Adult Mammalian Brain
- Dynamics of cell proliferation in the adult dentate gyrus of two inbred strains of mice.
- Neuroprotective and neurorestorative signal transduction mechanisms in brain aging: modification by genes, diet and behavior.
- Induction of adult neurogenesis: molecular manipulation of neural precursors in situ.
- Implication du BDNF dans l'étiopathogenèse et le traitement des troubles anxio-dépressifs : aspects précliniques.
- Partial serotonergic denervation decreases progenitor cell proliferation in the adult rat hippocampus, but has no effect on rat behavior in the forced swimming test.
- Serotonin receptor activation leads to neurite outgrowth and neuronal survival.
- Stimulation of neurogenesis in the hippocampus of the adult rat by fluoxetine requires rhythmic change in corticosterone.
- GABA(B) receptor function and subunit expression in the rat spinal cord as indicators of stress and the antinociceptive response to antidepressants.
- Selective serotonin depletion does not regulate hippocampal neurogenesis in the adult rat brain: differential effects of p-chlorophenylalanine and 5,7-dihydroxytryptamine.
- Reduced hippocampal neurogenesis and number of hilar neurones in streptozotocin‐induced diabetic mice: reversion by antidepressant treatment
- El Trastorno Bipolar: ¿Un trastorno de la regulación circadiana?
- Dopamine D2-like receptors and the antidepressant response.
- Electroconvulsive therapy in melancholia: the role of hippocampal neurogenesis
- Augmentation strategies for treatment‐resistant depression: a literature review
- The neural stem cell niche
- Cell cycle regulation, neurogenesis, and depression
- Adult neurogenesis, neuroinflammation and therapeutic potential of adult neural stem cells
- Imaging new neurons in vivo: a pioneering tool to study the cellular biology of depression?
- Serotonin Depletion Hampers Survival and Proliferation in Neurospheres Derived from Adult Neural Stem Cells
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