GABA(B) receptor function and subunit expression in the rat spinal cord as indicators of stress and the antinociceptive response to antidepressants.
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Summary
It was discovered that repeated daily exposure to a thermal stimulus or immobilization stress increases GABA(B(1a)) expression in the lumbar spinal cord, with no commensurate change in thermal pain threshold or GABA( B) receptor sensitivity.
- Type
- article
- Published
- 2006-01-12
- Cited by
- 36
- References
- 67
- OpenAlex
- https://openalex.org/W16368079
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:27663529
Keywords
Neutron diffraction, Isotope, Physics, Neutron, Spin (aerodynamics)
References
- Mechanical allodynia following contusion injury of the rat spinal cord is associated with loss of GABAergic inhibition in the dorsal horn
- Antidepressants and anticonvulsants for diabetic neuropathy and postherpetic neuralgia: a quantitative systematic review.
- Antidepressants as analgesics: a review of randomized controlled trials.
- Partial Peripheral Nerve Injury Promotes a Selective Loss of GABAergic Inhibition in the Superficial Dorsal Horn of the Spinal Cord
- GABAB-receptor subtypes assemble into functional heteromeric complexes
- Upregulation of gamma-aminobutyric acid (GABA) B binding sites in rat frontal cortex: a common action of repeated administration of different classes of antidepressants and electroshock.
- GABA(B) receptors couple directly to the transcription factor ATF4.
- Cardiovascular responses to acute hypoxia in dogs pretreated with benserazide and L-DOPA.
- GABA mechanisms and antinociception in mice with ligated sciatic nerve.
- Repeated administration of desipramine and a GABAB receptor antagonist, CGP 36742, discretely up‐regulates GABAB receptor binding sites in rat frontal cortex
- Inhibitory effects of spinal baclofen on spinal dorsal horn neurones in inflamed and neuropathic rats in vivo.
- A comparison of the antinociceptive responses to the GABA-receptor agonists THIP and baclofen.
- The GABAB receptor interacts directly with the related transcription factors CREB2 and ATFx.
- Molecular mechanisms of GABA(B) receptor activation: new insights from the mechanism of action of CGP7930, a positive allosteric modulator.
- Chronic antidepressants and GABA "B" receptors: a GABA hypothesis of antidepressant drug action.
- Dorsal horn synaptosomal content of aspartate, glutamate, glycine and GABA are differentially altered following chronic constriction injury to the rat sciatic nerve.
- The effects of GABAB agonists and gabapentin on mechanical hyperalgesia in models of neuropathic and inflammatory pain in the rat
- A single intrathecal injection of GABA permanently reverses neuropathic pain after nerve injury.
- Baclofen as an adjuvant analgesic.
- Ontogeny of GABA(B) receptor subunit expression and function in the rat spinal cord.
Cited by
- Schmerz aus psychosomatischer Sicht unter Berücksichtigung neuerer Forschungsergebnisse
- Effets antalgiques des antidépresseurs monoaminergiques : de la dépression à la neuropathie : approche préclinique
- The GABAB receptor as a target for antidepressant drug action
- Identifying the role of pre-and postsynaptic GABAB receptors in behavior
- The role of GABA in the mediation and perception of pain.
- Monoaminergic Antidepressants in the Relief of Pain: Potential Therapeutic Utility of Triple Reuptake Inhibitors (TRIs)
- Inhibitory effect of chronic oral treatment with fluoxetine on capsaicin-induced external carotid vasodilatation in anaesthetised dogs
- The Neuraxial Effects of Intraspinal Amitriptyline at Low Concentrations
- The genetics of selective serotonin reuptake inhibitors.
- Peripheral and spinal GABAergic regulation of incisional pain in rats
- Effects of inhibitory amino acids on expression of GABAA Rα and glycine Rα1 in hypoxic rat cortical neurons during development
- Amitriptyline prevents thermal hyperalgesia and modifications in rat spinal cord GABA(B) receptor expression and function in an animal model of neuropathic pain.
- The role of GABAB receptors in depression and antidepressant‐related behavioural responses
- Antidepressants and pain.
- Efficacy of Antidepressants as Analgesics: A Review
- Vom Schmerz zur somatoformen Ausweitung
- The Role of GABAB(1) Receptor Isoforms in Anxiety and Depression: Genetic and Pharmacological Studies in the Mouse
- Advances in spinal cord stimulation - enhancement of efficacy, improved surgical technique and a new indication
- Pharmacokinetics of intravenous and oral amitriptyline and its active metabolite nortriptyline in Greyhound dogs.
- Chemistry and pharmacology of GABAB receptor ligands.
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