Age-related effects on hippocampal precursor cell subpopulations and neurogenesis.
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Summary
Examination of age-related effects on total number and proliferation rate of distinct precursor cell populations in the dentate gyrus of 3 and 16 months old transgenic pNestin-GFP mice revealed a significant reduction of all proliferating precursor subtypes in aged mice compared to young controls.
- Type
- article
- Published
- 2011-10-01
- Cited by
- 111
- References
- 50
- OpenAlex
- https://openalex.org/W1979615967
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:207158566
Keywords
Neurogenesis, Dentate gyrus, Subgranular zone, Doublecortin, Hippocampal formation
References
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- Do glucocorticoid concentrations rise with age in the rat?
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- Cell types, lineage, and architecture of the germinal zone in the adult dentate gyrus
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- Newly born cells in the ageing dentate gyrus display normal migration, survival and neuronal fate choice but endure retarded early maturation
- NMDA receptor antagonist treatment increases the production of new neurons in the aged rat hippocampus.
- Age‐related production of new granule cells in the adult dentate gyrus
Cited by
- The impact of age on number and distribution of proliferating cells in subgranular zone in adult mouse brain
- Altérations cellulaires hippocampiques liées à l'âge et récupération cognitive induite par un enrichissement environnemental chez les souris Tg2576 modèles de la maladie d’Alzheimer
- Aging microglia: relevance to cognition and neural plasticity.
- Reversal of age-associated cognitive deficits is accompanied by increased plasticity-related gene expression after chronic antidepressant administration in middle-aged mice.
- Quiescence and cell fate regulation are essential for preserving adult stem cell number and function
- CXCR4 prevents dispersion of granule neuron precursors in the adult dentate gyrus
- Role of adult hippocampal neurogenesis in cognition in physiology and disease: pharmacological targets and biomarkers.
- Psychosocial influences on the dynamics of adult hippocampal neurogenesis
- Premature aging of the hippocampal neurogenic niche in adult Bmal1‐ deficient mice
- Age-Associated Increase in BMP Signaling inhibits Hippocampal Neurogenesis
- Systemic attenuation of the TGF-β pathway by a single drug simultaneously rejuvenates hippocampal neurogenesis and myogenesis in the same old mammal
- A voyage to Mars: Space radiation, aging, and nutrition
- Luteinizing hormone downregulation but not estrogen replacement improves ovariectomy-associated cognition and spine density loss independently of treatment onset timing
- Effects of Microglia on Neurogenesis
- Functional dysregulation of stem cells during aging: a focus on skeletal muscle stem cells
- Ageing stem and progenitor cells: implications for rejuvenation of the central nervous system
- Repeated Administration of PEP-1-Cu,Zn-Superoxide Dismutase and PEP-1-Peroxiredoxin-2 to Senescent Mice Induced by d-galactose Improves the Hippocampal Functions
- A high-fat diet impairs neurogenesis: involvement of lipid peroxidation and brain-derived neurotrophic factor.
- NEUROGENESIS, INFLAMMATION AND BEHAVIOR
- Polygenic Effects of Common Single-Nucleotide Polymorphisms on Life Span: When Association Meets Causality
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