Jaks and STATs: biological implications.
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Summary
The Jak-STAT pathway is the focus of this chapter, a novel mechanism in which cytosolic latent transcription factors, known as signal transducers and activators of transcription (STATs), are tyrosine phosphorylated by Janus family tyrosin kinases (Jaks), allowing STAT protein dimerization and nuclear translocation.
- Type
- review
- Published
- 1998-04-01
- Cited by
- 1,927
- References
- 183
- OpenAlex
- https://openalex.org/W2131666890
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:6570812
Keywords
Biology, stat, Signal transduction, Cell biology, Janus kinase
References
- The proteins of ISGF-3, the interferon alpha-induced transcriptional activator, define a gene family involved in signal transduction.
- Involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells
- Jaks, STATs, cytokine signal transduction, and immunoregulation: are we there yet?
- tyk2, prototype of a novel class of non-receptor tyrosine kinase genes.
- An IL‐2 response element in the human IL‐2 receptor alpha chain promoter is a composite element that binds Stat5, Elf‐1, HMG‐I(Y) and a GATA family protein.
- Identification and chromosomal mapping of new human tyrosine kinase genes.
- A novel cytokine‐inducible gene CIS encodes an SH2‐containing protein that binds to tyrosine‐phosphorylated interleukin 3 and erythropoietin receptors.
- Interleukin‐3, granulocyte‐macrophage colony stimulating factor and interleukin‐5 transduce signals through two STAT5 homologs.
- JAK3: a novel JAK kinase associated with terminal differentiation of hematopoietic cells.
- DNA binding of in vitro activated Stat1 alpha, Stat1 beta and truncated Stat1: interaction between NH2‐terminal domains stabilizes binding of two dimers to tandem DNA sites.
- Ligand‐induced IFN gamma receptor tyrosine phosphorylation couples the receptor to its signal transduction system (p91).
- CIS, a cytokine inducible SH2 protein, is a target of the JAK-STAT5 pathway and modulates STAT5 activation.
- JAK2, a third member of the JAK family of protein tyrosine kinases.
- Differential tyrosine phosphorylation of the IFNAR chain of the type I interferon receptor and of an associated surface protein in response to IFN‐alpha and IFN‐beta.
- Interleukin‐2 activation of STAT5 requires the convergent action of tyrosine kinases and a serine/threonine kinase pathway distinct from the Raf1/ERK2 MAP kinase pathway.
- Interleukin‐3 signals through multiple isoforms of Stat5.
- An amino acid substitution in the Drosophila hopTum‐l Jak kinase causes leukemia‐like hematopoietic defects.
- Activation of a Drosophila Janus kinase (JAK) causes hematopoietic neoplasia and developmental defects.
- p135tyk2, an interferon-alpha-activated tyrosine kinase, is physically associated with an interferon-alpha receptor.
- A new protein containing an SH2 domain that inhibits JAK kinases
Cited by
- Transcriptional regulation in neutrophils: teaching old cells new tricks.
- Interleukin-10 (IL-10) selectively enhances CIS3/SOCS3 mRNA expression in human neutrophils: evidence for an IL-10-induced pathway that is independent of STAT protein activation.
- Generation of K581A Mutation and Production of Recombinant JAK2 Protein
- The Epstein-Barr virus and its association with human cancers.
- Trichodion, a new inhibitor of inflammatory signal transduction pathways from a Trichosporiella species
- Inhibition of Jak3 tyrosine kinase by PNU156804 blocks rat heart allograft rejection.
- Focal Adhesion Kinase Activates Stat1 in Integrin-mediated Cell Migration and Adhesion*
- Cell function-based flow cytometry.
- Comparison of five retrovirus vectors containing the human IL-2 receptor gamma chain gene for their ability to restore T and B lymphocytes in the X-linked severe combined immunodeficiency mouse model.
- Signal transducer and activator of transcription 6 (STAT-6) expression and function in asthmatic bronchial epithelium.
- In vivo activation of JAK2/STAT‐3 pathway during angiogenesis induced by GM‐CSF
- The CD23b promoter is a target for NF-AT transcription factors in B-CLL cells.
- JAK/STAT but Not ERK1/ERK2 Pathway Mediates Interleukin (IL)-6/Soluble IL-6R Down-regulation of Type II Collagen, Aggrecan Core, and Link Protein Transcription in Articular Chondrocytes
- A Role for STAT5 in the Pathogenesis of IL-2-Induced Glucocorticoid Resistance1
- Dual mechanism of signal transducer and activator of transcription 5 activation by the insulin receptor.
- Resistance to Acute Babesiosis Is Associated with Interleukin-12- and Gamma Interferon-Mediated Responses and Requires Macrophages and Natural Killer Cells
- A new modality for immunosuppression: targeting the JAK/STAT pathway
- Jak kinase activity is required for lymphoma invasion and metastasis
- Immunosuppression by the JAK3 Inhibitor CP-690,550 Delays Rejection and Significantly Prolongs Kidney Allograft Survival in Nonhuman Primates
- The possible role of the Jak/STAT pathway in lymphocytes at the fetomaternal interface.
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