Interleukin‐3, granulocyte‐macrophage colony stimulating factor and interleukin‐5 transduce signals through two STAT5 homologs.
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Summary
Analysis of bandshift complexes with available antibodies to the known STATs suggests that IL‐3 activates the DNA‐binding ability of STAT5, a protein which was originally characterized as a prolactin‐responsive transcription factor in sheep.
- Type
- article
- Published
- 1995-03-01
- Cited by
- 665
- References
- 51
- Access
- Open access
- OpenAlex
- https://openalex.org/W77986286
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:45519007
Keywords
Biology, Granulocyte macrophage colony-stimulating factor, STAT5, Interleukin 3, Granulocyte macrophage colony-stimulating factor receptor
References
- Proteins of transcription factor ISGF-3: one gene encodes the 91-and 84-kDa ISGF-3 proteins that are activated by interferon alpha.
- The proteins of ISGF-3, the interferon alpha-induced transcriptional activator, define a gene family involved in signal transduction.
- A single phosphotyrosine residue of Stat91 required for gene activation by interferon-gamma.
- Ligand‐induced IFN gamma receptor tyrosine phosphorylation couples the receptor to its signal transduction system (p91).
- Interleukin-3 regulates the activity of the LYN protein-tyrosine kinase in myeloid-committed leukemic cell lines.
- Interleukin 3‐specific tyrosine phosphorylation of a membrane glycoprotein of Mr 150,000 in multi‐factor‐dependent myeloid cell lines.
- Critical cytoplasmic domains of the common beta subunit of the human GM‐CSF, IL‐3 and IL‐5 receptors for growth signal transduction and tyrosine phosphorylation.
- Characterization of a 97-kDa phosphotyrosylprotein regulated by multiple cytokines.
- Prolactin induces phosphorylation of Tyr694 of Stat5 (MGF), a prerequisite for DNA binding and induction of transcription.
- Two distinct functional high affinity receptors for mouse interleukin‐3 (IL‐3).
- Mammary gland-specific nuclear factor is present in lactating rodent and bovine mammary tissue and composed of a single polypeptide of 89 kDa.
- Interleukin-3 stimulates the tyrosine phosphorylation of the 140-kilodalton interleukin-3 receptor.
- Tyrosine phosphorylation of receptor beta subunits and common substrates in response to interleukin-3 and granulocyte-macrophage colony-stimulating factor.
- JAK2 associates with the beta c chain of the receptor for granulocyte-macrophage colony-stimulating factor, and its activation requires the membrane-proximal region
- Interleukin 3 binds to a 140-kDa phosphotyrosine-containing cell surface protein.
- Interferon-dependent tyrosine phosphorylation of a latent cytoplasmic transcription factor.
- JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin.
- Structure of the murine Jak2 protein-tyrosine kinase and its role in interleukin 3 signal transduction.
- Identification of JAK2 as a growth hormone receptor-associated tyrosine kinase.
- Tyrosine phosphorylation of DNA binding proteins by multiple cytokines.
Cited by
- Activation of the STAT3/Acute Phase Response Factor Transcription Factor by Interleukin-5 (*)
- Endocrine, paracrine and autocrine actions of prolactin on immune cells.
- Cytoplasmic Domains of the Human Granulocyte-Macrophage Colony-stimulating Factor (GM-CSF) Receptor β Chain (hβc) Responsible for Human GM-CSF-induced Myeloid Cell Differentiation*
- Differential influence of tyrosine residues of the common receptor beta subunit on multiple signals induced by human GM-CSF.
- Caco-2 cell differentiation is associated with a decrease in stat protein levels and binding
- Role of JAK2 signal transductional pathway in activation and survival of human peripheral eosinophils by interferon‐gamma (IFN‐γ)
- Regulation of granulopoiesis by transcription factors and cytokine signals
- DNA Binding Specificity of Different STAT Proteins
- In vivo activation of JAK2/STAT‐3 pathway during angiogenesis induced by GM‐CSF
- Prolactin Mediated Intracellular Signaling in Mammary Epithelial Cells
- Stat3-dependent induction of interleukin-3 receptor expression in leukemia inhibitory factor-stimulated M1 mouse leukemia cells.
- Regulation of Cell Proliferation by Interleukin-3-induced Nuclear Translocation of Pyruvate Kinase*
- Thrombopoietin signal transduction in purified murine megakaryocytes.
- Regulators of growth hormone signaling.
- Interleukin-4 induced leukocyte differentiation
- STAT5 activation contributes to growth and viability in Bcr/Abl-transformed cells.
- A novel cytokine‐inducible gene CIS encodes an SH2‐containing protein that binds to tyrosine‐phosphorylated interleukin 3 and erythropoietin receptors.
- Granulocyte-macrophage colony-stimulating factor stimulation results in phosphorylation of cAMP response element-binding protein through activation of pp90RSK.
- A role for STAT family transcription factors in myeloid differentiation.
- FLT3 Gene Mutation and STAT5 Protein Activation in Egyptian Acute Myeloid Leukemia Patients
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