Jaks, STATs, cytokine signal transduction, and immunoregulation: are we there yet?
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Summary
Now that a variety of knockout mice have been generated, these mice will provide excellent vehicles for reconstitution studies with mutated version of Jaks and STATs to elucidate structure–function relationships as they relate to the organism.
- Type
- article
- Published
- 1997-07-01
- Cited by
- 420
- References
- 132
- Access
- Open access
- OpenAlex
- https://openalex.org/W9252115
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:26318463
Keywords
Art, Theology, Philosophy
References
- A single phosphotyrosine residue of Stat91 required for gene activation by interferon-gamma.
- Phosphorylated interferon‐alpha receptor 1 subunit (IFNaR1) acts as a docking site for the latent form of the 113 kDa STAT2 protein.
- Ligand‐induced IFN gamma receptor tyrosine phosphorylation couples the receptor to its signal transduction system (p91).
- Constitutive activation of STAT proteins in primary lymphoid and myeloid leukemia cells and in Epstein-Barr virus (EBV)-related lymphoma cell lines.
- Complementation of a mutant cell line: central role of the 91 kDa polypeptide of ISGF3 in the interferon‐alpha and ‐gamma signal transduction pathways.
- Interleukin‐2 activation of STAT5 requires the convergent action of tyrosine kinases and a serine/threonine kinase pathway distinct from the Raf1/ERK2 MAP kinase pathway.
- An amino acid substitution in the Drosophila hopTum‐l Jak kinase causes leukemia‐like hematopoietic defects.
- Activation of a Drosophila Janus kinase (JAK) causes hematopoietic neoplasia and developmental defects.
- The protein tyrosine kinase JAK1 complements defects in interferon-α/β and -γ signal transduction
- The rapid inactivation of nuclear tyrosine phosphorylated Stat1 depends upon a protein tyrosine phosphatase.
- Functional subdomains of STAT2 required for preassociation with the alpha interferon receptor and for signaling
- PTP1D is a positive regulator of the prolactin signal leading to beta‐casein promoter activation.
- Activation of STAT4 by IL-12 and IFN-alpha: evidence for the involvement of ligand-induced tyrosine and serine phosphorylation.
- The amino terminus of JAK3 is necessary and sufficient for binding to the common gamma chain and confers the ability to transmit interleukin 2-mediated signals.
- Cytokine receptor signalling
- Cooperative DNA Binding and Sequence-Selective Recognition Conferred by the STAT Amino-Terminal Domain
- Interferon-dependent tyrosine phosphorylation of a latent cytoplasmic transcription factor.
- A transcription factor with SH2 and SH3 domains is directly activated by an interferon α-induced cytoplasmic protein tyrosine kinase(s)
- A protein tyrosine kinase in the interferon alpha/beta signaling pathway.
- Defective lymphoid development in mice lacking expression of the common cytokine receptor gamma chain.
Cited by
- Molecular interactions of Salmonella with the host epithelium in the presence of commensals
- Erythropoietin receptor and STAT5-specific pathways promote SKT6 cell hemoglobinization.
- Specificity, diversity, and convergence in VEGF and TNF‐α signaling events leading to tissue factor up regulation via EGR‐1 in endothelial cells
- JAKing up immunosuppression
- A new modality for immunosuppression: targeting the JAK/STAT pathway
- Mucosal T lymphocytes—peacekeepers and warriors
- Contribution of LCMV transgenic models to understanding T lymphocyte development, activation, tolerance, and autoimmunity.
- Multiple roles of STAT3 in cardiovascular inflammatory responses.
- Characterization of the in vitro kinase activity of a partially purified soluble GST/JAK2 fusion protein
- The role of interleukin-12 for mTOR regulation of memory CTLs
- analyses of 10 patients and outcomes of stem cell transplantation Janus kinase 3 (JAK3) deficiency: clinical, immunologic, and molecular
- Selective disruption of interleukin 4 autocrine-regulated loop by a tyrosine kinase inhibitor restricts activity of T-helper 2 cells.
- The role of STAT1 in chlamydia-induced type I interferon responses in oviduct epithelium
- Further evidence for the involvement of insulin receptor substrates in epidermal growth factor-induced activation of phosphatidylinositol 3-kinase.
- A model for assembly and activation of the GM-CSF, IL-3 and IL-5 receptors: insights from activated mutants of the common beta subunit.
- Cutting edge: TCR stimulation by antibody and bacterial superantigen induces Stat3 activation in human T cells.
- Decidual NK Cell‐Derived Conditioned Medium (dNK‐CM) Mediates VEGF‐C Secretion in Extravillous Cytotrophoblasts
- Simultaneous induction of NKG2D and NKG2D ligand for promoting immune surveillance by IL-12 plus doxorubicin treatment
- Allograft Rejection Requires STAT5a/b-Regulated Antiapoptotic Activity in T Cells but Not B Cells1
- Involvement of SHP-2 in multiple aspects of IL-2 signaling: evidence for a positive regulatory role.
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