let-7 regulates self renewal and tumorigenicity of breast cancer cells.
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Summary
Let-7 regulates multiple BT-IC stem cell-like properties by silencing more than one target, and miRNA expression in self-renewing and differentiated cells from breast cancer lines and in breast T-IC and non-BT-IC from 1 degrees breast cancers is compared.
- Type
- article
- Published
- 2007-12-14
- Cited by
- 1,988
- References
- 43
- Access
- Open access
- OpenAlex
- https://openalex.org/W2131596261
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:14103196
Keywords
Biology, Gene silencing, Cancer research, microRNA, Cell culture
References
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- Disrupting the Pairing Between let-7 and Hmga2 Enhances Oncogenic Transformation
- let-7 microRNA functions as a potential growth suppressor in human colon cancer cells.
- High mobility group A2 potentiates genotoxic stress in part through the modulation of basal and DNA damage-dependent phosphatidylinositol 3-kinase-related protein kinase activation.
- Cancer Stem Cells and Metastasis: Lethal Seeds
- The MicroRNA Pathway Plays a Regulatory Role in Stem Cell Division
- Prospective identification of tumorigenic breast cancer cells
- Molecular definition of breast tumor heterogeneity.
- Expression of high-mobility-group-protein HMGI-C mRNA in the peripheral blood is an independent poor prognostic indicator for survival in metastatic breast cancer
- Isolation and in vitro propagation of tumorigenic breast cancer cells with stem/progenitor cell properties.
- Glioma stem cells promote radioresistance by preferential activation of the DNA damage response
- Mesenchyme Forkhead 1 (FOXC2) plays a key role in metastasis and is associated with aggressive basal-like breast cancers
- Targeting RAS signalling pathways in cancer therapy
Cited by
- Probabilistic Models for Collecting, Analyzing, and Modeling Expression Data
- Regulation of cyclin dependent kinase 6 by microRNA 124 in medulloblastoma
- MicroRNAs in breast cancer
- 肺癌侧群细胞microRNA表达谱检测及初步分析
- The guardians of the genome (p53, TA-p73, and TA-p63) are regulators of tumor suppressor miRNAs network
- Biology of the Mi-2/NuRD Complex in SLAC (Stemness, Longevity/Ageing, and Cancer)
- MicroRNA 34c Gene Down-regulation via DNA Methylation Promotes Self-renewal and Epithelial-Mesenchymal Transition in Breast Tumor-initiating Cells*
- HMGA2 protein expression in ovarian serous carcinoma effusions, primary tumors, and solid metastases
- The involvement of microRNAs in malignant transformation.
- The miR-17-92 cluster counteracts quiescence and chemoresistance of pancreatic cancer stem cells
- MicroRNA-224 targets RKIP to control cell invasion and expression of metastasis genes in human breast cancer cells.
- Loss of Mel‐18 enhances breast cancer stem cell activity and tumorigenicity through activating Notch signaling mediated by the Wnt/TCF pathway
- MiR-19b/20a/92a regulates the self-renewal and proliferation of gastric cancer stem cells
- Emerging Role of MicroRNAs in Cancer and Cancer Stem Cells
- Colon cancer cells escape 5FU chemotherapy-induced cell death by entering stemness and quiescence associated with the c-Yes/YAP axis
- miRNA therapy targeting cancer stem cells: a new paradigm for cancer treatment and prevention of tumor recurrence.
- Activation of LINE-1 Retrotransposon Increases the Risk of Epithelial-Mesenchymal Transition and Metastasis in Epithelial Cancer
- Nanomedicine-mediated cancer stem cell therapy.
- Uncovering the roles of long non-coding RNAs in cancer stem cells
- PMP22 Regulates Self-Renewal and Chemoresistance of Gastric Cancer Cells
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