The microRNA pathway and cancer
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Summary
This review summarizes how miRNAs are produced, assembled into RISC, and regulate target mRNAs, and discusses how the miRNA pathway is involved in cancer.
- Type
- review
- Published
- 2010-11-01
- Cited by
- 250
- References
- 80
- Access
- Open access
- OpenAlex
- https://openalex.org/W2026936876
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:45153515
Keywords
microRNA, Gene silencing, RNA-induced silencing complex, Biology, Gene
References
- MicroRNA genes are transcribed by RNA polymerase II
- Short RNAs repress translation after initiation in mammalian cells.
- Human let-7a miRNA blocks protein production on actively translating polyribosomes
- Abnormal microRNA-16 locus with synteny to human 13q14 linked to CLL in NZB mice.
- Drosophila miR2 induces pseudo-polysomes and inhibits translation initiation
- p53 — a Jack of all trades but master of none
- Oncomirs — microRNAs with a role in cancer
- ATP-dependent human RISC assembly pathways
- The nuclear RNase III Drosha initiates microRNA processing
- The DEAD box protein p68: a novel transcriptional coactivator of the p53 tumour suppressor
- Genome analysis of the platypus reveals unique signatures of evolution
- MicroRNA-dependent localization of targeted mRNAs to mammalian P-bodies
- Principles of MicroRNA–Target Recognition
- The biological basis for microRNA target restriction to the 3' untranslated region in mammalian mRNAs
- miR-21: a small multi-faceted RNA
- MicroRNA signatures in human cancers
- Modulation of microRNA processing by p53
- Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs.
- Argonaute 2/RISC resides in sites of mammalian mRNA decay known as cytoplasmic bodies
- In vitro assembly of plant RNA-induced silencing complexes facilitated by molecular chaperone HSP90.
Cited by
- miRNA-504 inhibits p53-dependent vascular smooth muscle cell apoptosis and may prevent aneurysm formation
- Long non-coding RNA UCA1 promoted the growth of adrenocortical cancer cells via modulating the miR-298-CDK6 axis.
- Zellbiologische Effekte aktivierter Gerinnungsfaktoren auf Tumorzellen
- MicroRNA Cancer Regulation
- Structural characterization of the minimal human RISC-loading complex
- Aberrant expression of microRNA in gliomas: Molecular mechanisms, functional consequences and clinical significance
- Investigating the modulation of viral translation by the Hepatitis C virus nonstructural protein 5A
- Suppressing RNA silencing with small molecules and the viral suppressor of RNA silencing protein p19.
- Arginylation in a Partially Purified Fraction of 150k × g Supernatants of Axoplasm and Injured Vertebrate Nerves.
- Common polymorphisms of the microRNA genes (miR-146a and miR-196a-2) and gastric cancer risk: an updated meta-analysis.
- Designing a gold nanoparticle‐based nanocarrier for microRNA transfection into the prostate and breast cancer cells
- microRNAs in Human Cancer
- Hepatitis C viral protein translation: mechanisms and implications in developing antivirals
- Análise da expressão de microRNAs e alvos candidatos em carcinomas epidermóides de cabeça e pescoço
- MiR-499 Enhances the Cisplatin Sensitivity of Esophageal Carcinoma Cell Lines by Targeting DNA Polymerase β
- ERGIC3, which is regulated by miR-203a, is a potential biomarker for non-small cell lung cancer
- MiR-302c-3p suppresses invasion and proliferation of glioma cells via down-regulating metadherin (MTDH) expression
- Common genetic polymorphisms in pre-microRNAs and risk of bladder cancer
- Unraveling the Mystery of Cancer by Secretory microRNA: Horizontal microRNA Transfer between Living Cells
- Pathway analysis of cancer-associated microRNA targets.
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