Upstream and downstream of mTOR.
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Summary
Both the upstream components of the signaling pathway(s) that activates mammalian TOR (mTOR) and the downstream targets that affect protein synthesis are described.
- Type
- review
- Published
- 2004-08-15
- Cited by
- 4,380
- References
- 215
- Access
- Open access
- OpenAlex
- https://openalex.org/W2129585918
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:128133
Keywords
Biology, PI3K/AKT/mTOR pathway, Effector, Cell biology, TOR signaling
References
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- Two Motifs in the Translational Repressor PHAS-I Required for Efficient Phosphorylation by Mammalian Target of Rapamycin and for Recognition by Raptor*
- Sirolimus for the prevention of in-stent restenosis in a coronary artery.
- mTOR-Dependent Regulation of Ribosomal Gene Transcription Requires S6K1 and Is Mediated by Phosphorylation of the Carboxy-Terminal Activation Domain of the Nucleolar Transcription Factor UBF†
- The TOR signalling pathway and growth control in yeast.
- mRNAs containing extensive secondary structure in their 5′ non‐coding region translate efficiently in cells overexpressing initiation factor eIF‐4E.
- Rheb promotes cell growth as a component of the insulin/TOR signalling network
- 20 Translational Control and Cancer
- Hypoinsulinaemia, glucose intolerance and diminished β-cell size in S6K1-deficient mice
- Adipose tissue reduction in mice lacking the translational inhibitor 4E-BP1
- rheb, a growth factor- and synaptic activity-regulated gene, encodes a novel Ras-related protein.
- Regulated phosphorylation and low abundance of HeLa cell initiation factor eIF-4F suggest a role in translational control. Heat shock effects on eIF-4F.
- Regulation of initiation factors during translational repression caused by serum depletion. Covalent modification.
- Cell-autonomous regulation of cell and organ growth in Drosophila by Akt/PKB
- 6 Regulation of Ribosomal Recruitment in Eukaryotes
- The TSC1 tumour suppressor hamartin regulates cell adhesion through ERM proteins and the GTPase Rho
- An encore for ribosome biogenesis in the control of cell proliferation
- Insulin induction of ornithine decarboxylase. Importance of mRNA secondary structure and phosphorylation of eucaryotic initiation factors eIF-4B and eIF-4E.
Cited by
- Manipulation of host cell signaling pathways and translation factors during poxvirus infection
- A PI3K-mediated negative feedback regulates Drosophila motor neuron excitability
- Effect and mechanism of panaxoside Rg1 on neovascularization in myocardial infarction rats
- Cibles moléculaires de la myostatine impliquées dans l'hypertrophie musculaire chez la souris et le bovin
- Translationale Forschung bei Kopf-Hals-Tumoren
- Analysis of phosphoproteomics data.
- Functional control of HIV-1 post-transcriptional gene expression by host cell factors
- Nutritive Phagocyte Incubation Chambers Provide a Structural and Nutritive Microenvironment for Germ Cells of Strongylocentrotus droebachiensis, the Green Sea Urchin
- Rapamycin analogs with differential binding specificity permit orthogonal control of protein activity.
- TOR signaling in growth and metabolism.
- Therapeutic targets: MTOR and related pathways
- The energy sensing LKB1–AMPK pathway regulates p27kip1 phosphorylation mediating the decision to enter autophagy or apoptosis
- p21-activated Kinase 1 Is Activated through the Mammalian Target of Rapamycin/p70 S6 Kinase Pathway and Regulates the Replication of Hepatitis C Virus in Human Hepatoma Cells*
- Regulation of Endothelial Cell Cycle by Laminar Versus Oscillatory Flow: Distinct Modes of Interactions of AMP-Activated Protein Kinase and Akt Pathways
- Rheb-TOR signaling promotes protein synthesis, but not glucose or amino acid import, in Drosophila
- FOXO1 Regulates the Expression of 4E-BP1 and Inhibits mTOR Signaling in Mammalian Skeletal Muscle*
- Insulin is a Two-Edged Knife on the Brain
- Fission yeast TORC1 regulates phosphorylation of ribosomal S6 proteins in response to nutrients and its activity is inhibited by rapamycin
- Building blocks for protein interaction devices
- Glucose regulation of β‐cell stress in type 2 diabetes
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