In vivo reprogramming of adult pancreatic exocrine cells to β-cells
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Summary
This study identifies a specific combination of three transcription factors (Ngn3) Pdx1 and Mafa that reprograms differentiated pancreatic exocrine cells in adult mice into cells that closely resemble β-cells, and suggests a general paradigm for directing cell reprogramming without reversion to a pluripotent stem cell state.
- Type
- article
- Published
- 2008-08-27
- Cited by
- 1,949
- References
- 46
- Access
- Open access
- OpenAlex
- https://openalex.org/W2126780067
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:205214877
Keywords
Reprogramming, PDX1, Cell biology, Biology, Induced pluripotent stem cell
References
- Lineage tracing and characterization of insulin-secreting cells generated from adult pancreatic acinar cells.
- Stem Cells Units of Development, Units of Regeneration, and Units in Evolution
- Comparison of Adenoviral and Adeno-Associated Viral Vectors for Pancreatic Gene Delivery In Vivo
- Molecular basis of transdifferentiation of pancreas to liver
- Stepwise reprogramming of B cells into macrophages.
- In vitro generation of insulin-producing beta cells from adult exocrine pancreatic cells
- Induced Pluripotent Stem Cell Lines Derived from Human Somatic Cells
- Adenovirus transduction is required for the correction of diabetes using Pdx-1 or Neurogenin-3 in the liver.
- fgf20 Is Essential for Initiating Zebrafish Fin Regeneration
- A multipotent progenitor domain guides pancreatic organogenesis.
- MyoD converts primary dermal fibroblasts, chondroblasts, smooth muscle, and retinal pigmented epithelial cells into striated mononucleated myoblasts and multinucleated myotubes.
- Conversion of mature B cells into T cells by dedifferentiation to uncommitted progenitors
- Ectopically expressed PDX-1 in liver initiates endocrine and exocrine pancreas differentiation but causes dysmorphogenesis.
- Plasticity and reprogramming of differentiated cells in amphibian regeneration
- Reprogramming of human somatic cells to pluripotency with defined factors
- In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state
- Transdetermination in cells.
- Gene regulatory factors in pancreatic development
- Role of VEGF-A in vascularization of pancreatic islets.
- Nuclear reprogramming and pluripotency
Cited by
- Current research concerning the RAS in pancreatic stem cells.
- Cdk4 Regulates Recruitment of Quiescent β-Cells and Ductal Epithelial Progenitors to Reconstitute β-Cell Mass
- Disparate Companions: Tissue Engineering Meets Cancer Research
- Moving toward personalized cell-based interventions for adrenal cortical disorders: part 2--Human diseases and tissue engineering.
- Return to youth with Sox17.
- Chemerin regulates β-cell function in mice
- A case of cellular alchemy: lineage reprogramming and its potential in regenerative medicine.
- Oreocnide integrifolia Flavonoids Augment Reprogramming for Islet Neogenesis and β-Cell Regeneration in Pancreatectomized BALB/c Mice
- Restoring stem cell function in aged tissues by direct reprogramming?
- A forward genetics approach to identify molecular drivers of liver cancer using Sleeping Beauty mouse models
- Insulin-Producing Cells Derived from Human Embryonic Stem Cells: Comparison of Definitive Endoderm- and Nestin-Positive Progenitor-Based Differentiation Strategies
- De Novo Formation of Insulin-Producing “Neo-β Cell Islets” from Intestinal Crypts
- Pancreatic Stem Cells Remain Unresolved
- Gene delivery in tissue engineering and regenerative medicine.
- THERAPY OF ENDOCRINE DISEASE: Islet transplantation for type 1 diabetes: so close and yet so far away.
- Gap junctional shuttling of miRNA--A novel pathway of intercellular gene regulation and its prospects in clinical application.
- Chromatin Regulators in Pancreas Development and Diabetes.
- [Tissue engineering of the tooth: directions of development, achievements and unresolved problems].
- Reprogramming Glia Into Neurons in the Peripheral Auditory System as a Solution for Sensorineural Hearing Loss: Lessons From the Central Nervous System
- Stem cells: past, present, and future
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