Tumor hypoxia: definitions and current clinical, biologic, and molecular aspects.
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Summary
Because malignant tumors no longer execute functions necessary for homeostasis (such as the production of adequate amounts of adenosine triphosphate), the physiology-based definitions of the term "hypoxia" are not necessarily valid for malignant tumor patients.
- Type
- review
- Published
- 2001-02-21
- Cited by
- 2,686
- References
- 166
- Access
- Open access
- OpenAlex
- https://openalex.org/W2125257427
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:2201522
Keywords
Hypoxia (environmental), Tumor hypoxia, Homeostasis, Microcirculation, Cancer research
References
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- Modern Cardiovascular Physiology
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- Quantifying Transient Hypoxia in Human Tumor Xenografts by Flow Cytometry
- Time-Domain Optical Mammography SoftScan
- Targeting hypoxia and angiogenesis through HIF-1alpha inhibition
- A novel 3‐dimensional culture system as an in vitro model for studying oral cancer cell invasion
- Selective silencing of the hypoxia-inducible factor 1 target gene BNIP3 by histone deacetylation and methylation in colorectal cancer
- Neuroblastoma as an experimental model for neuronal differentiation and hypoxia-induced tumor cell dedifferentiation.
- Hypoxia-induced and stress-specific changes in chromatin structure and function.
- Investigation of biphasic tumor oxygen dynamics induced by hyperoxic gas intervention: the dynamic phantom approach.
- Basic Science Review: Nitric Oxide—Releasing Prosthetic Materials
- Limitations of dynamic contrast‐enhanced MRI in monitoring radiation‐induced changes in the fraction of radiobiologically hypoxic cells in human melanoma xenografts
- Ligand-Directed AAVP to Deliver a Therapeutic Transgene to Neuroendocrine Tumors of the Pancreas
- Sunitinib deregulates tumor adaptation to hypoxia by inhibiting HIF-1alpha synthesis in HT-29 colon cancer cells.
- Sphingosine kinase 1 pathway is involved in melatonin‐induced HIF‐1α inactivation in hypoxic PC‐3 prostate cancer cells
- Expression of oxidored nitro domain-containing protein 1(NOR1) impairs nasopharyngeal carcinoma cells adaptation to hypoxia and inhibits PDK1 expression
- The Warburg Effect: Evolving Interpretations Of An Established Concept
- The potential of clostridial spores as therapeutic delivery vehicles in tumour therapy.
- Photoacoustic lifetime imaging for direct in vivo tissue oxygen monitoring
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