Stress-Dependent Regulation of FOXO Transcription Factors by the SIRT1 Deacetylase
Explore this paper's citation graph
Summary
One way in which members of the Sir2 family of proteins may increase organismal longevity is by tipping FOXO-dependent responses away from apoptosis and toward stress resistance.
- Type
- article
- Published
- 2004-03-26
- Cited by
- 3,357
- References
- 27
- OpenAlex
- https://openalex.org/W2124898423
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:28937856
Keywords
FOXO3, Longevity, Transcription factor, Cell biology, Forkhead Transcription Factors
References
- Direct control of the Forkhead transcription factor AFX by protein kinase B
- The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans
- Why do we age?
- Sir2 links chromatin silencing, metabolism, and aging.
- Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1.
- Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans
- Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae.
- Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae
- A phylogenetically conserved NAD+-dependent protein deacetylase activity in the Sir2 protein family.
- Redox Regulation of Forkhead Proteins Through a p66shc-Dependent Signaling Pathway
- Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins.
- DNA Repair Pathway Stimulated by the Forkhead Transcription Factor FOXO3a Through the Gadd45 Protein
- Human SIR2 deacetylates p53 and antagonizes PML/p53‐induced cellular senescence
- daf-16: An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans.
- Sir2 regulates skeletal muscle differentiation as a potential sensor of the redox state.
- Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
- Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
- Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress
- hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase.
- FoxO6, a Novel Member of the FoxO Class of Transcription Factors with Distinct Shuttling Dynamics*
Cited by
- FOXO1, T-cell trafficking and immune responses.
- Involvement of sirtuins in life-span and aging related diseases.
- Silent information regulator 2 (SIRT1) attenuates oxidative stress-induced mesangial cell apoptosis via p53 deacetylation.
- Exercise Training Promotes SIRT1 Activity in Aged Rats
- FOXO3A Regulates Peroxiredoxin III Expression in Human Cardiac Fibroblasts*
- Foxo in the immune system
- Sirtuins — novel therapeutic targets to treat age-associated diseases
- Nutrition, sirtuins and aging
- Protective Role of SIRT1 in Diabetic Vascular Dysfunction
- Characterization of nuclear sirtuins: molecular mechanisms and physiological relevance.
- Sirtuins and Their Relevance to the Kidney
- Foxo3a Suppression of Urothelial Cancer Invasiveness through Twist1, Y-Box–Binding Protein 1, and E-Cadherin Regulation
- After the grape rush: sirtuins as epigenetic drug targets in neurodegenerative disorders.
- Resveratrol prevention of oxidative stress damage to lens epithelial cell cultures is mediated by forkhead box O activity.
- Sirtuin 1 in malignant transformation: friend or foe?
- On acetyl-CoA as a gauge of cellular metabolic state.
- Methylation by Set9 modulates FoxO3 stability and transcriptional activity
- Is Physical Activity Able to Modify Oxidative Damage in Cardiovascular Aging?
- Aberrantly activated EGFR contributes to enhanced IL-8 expression in COPD airways epithelial cells via regulation of nuclear FoxO3A
- Expansion of oligodendrocyte progenitor cells following SIRT1 inactivation in the adult brain
Related papers
- FOXO3 induces FOXO1-dependent autophagy by activating the AKT1 signaling pathway
- FoxO3 regulates hepatic glucose production
- Understanding the perspectives of forkhead transcription factors in delayed wound healing
- FOXO Transcriptional Factors and Long-Term Living
- FOXO Transcription Factors in Liver Function and Disease
- Role of Forkhead Transcription Factors in Diabetes-Induced Oxidative Stress
- The Dual Specificity Role of Transcription Factor FOXO in Type 2-diabetes and Cancer.
- Forkhead boxO Family Members Are Critical for Follicular Development and Luteinization.
- Does Calorie Restriction Modulate Inflammaging via FoxO Transcription Factors?
- Homocysteine alters Redox Regulation through Thioredoxin‐Interacting Protein: A Novel role of Forkhead Transcription Factor (FOXO‐3a/FKHR‐L1)