Role of oxidative stress in diabetic complications: a new perspective on an old paradigm.
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Summary
It is proposed that the increased chemical modification of proteins by carbohydrates and lipids in diabetes is the result of overload on metabolic pathways involved in detoxification of reactivecarbonyl species, leading to a general increase in steady-state levels of reactive carbonyl compounds formed by both oxidative and nonoxidative reactions.
- Type
- review
- Published
- 1999-01-01
- Cited by
- 2,559
- References
- 81
- OpenAlex
- https://openalex.org/W2124098523
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:25272224
Keywords
Oxidative stress, Diabetes mellitus, Chemistry, Oxidative phosphorylation, Glycation
References
- Presence of dopa and amino acid hydroperoxides in proteins modified with advanced glycation end products (AGEs): amino acid oxidation products as a possible source of oxidative stress induced by AGE proteins.
- Glucose autoxidation and protein modification. The potential role of 'autoxidative glycosylation' in diabetes.
- Immunohistochemical and ultrastructural detection of advanced glycation end products in atherosclerotic lesions of human aorta with a novel specific monoclonal antibody.
- Protein Cross-linking by the Maillard Reaction
- Pyruvate Improves Deleterious Effects of High Glucose on Activation of Pentose Phosphate Pathway and Glutathione Redox Cycle in Endothelial Cells
- Autoxidation products of both carbohydrates and lipids are increased in uremic plasma: is there oxidative stress in uremia?
- Lipid advanced glycosylation: pathway for lipid oxidation in vivo.
- Progression of Nephropathy in Spontaneous Diabetic Rats Is Prevented by OPB-9195, a Novel Inhibitor of Advanced Glycation
- Macrophage scavenger receptor mediates the endocytic uptake and degradation of advanced glycation end products of the Maillard reaction.
- Lipid peroxidation product, 4-hydroxynonenal and its conjugate with GSH are excellent substrates of bovine lens aldose reductase.
- Effects of Glycemic Control on Plasma 3-Deoxyglucosone Levels in NIDDM Patients
- Identification of fructose 3-phosphate in the lens of diabetic rats.
- Chronic Dosing With Aminoguanidine and Novel Advanced Glycosylation End Product-Formation Inhibitors Ameliorates Cross-Linking of Tail Tendon Collagen in STZ-Induced Diabetic Rats
- Early changes of lens metabolism after X-irradiation.
- Oxidative stress is found in amyloid deposits in systemic amyloidosis.
- Oxidative Stress and Diabetic Vascular Complications
- Aging, metabolism, and Alzheimer disease: review and hypotheses.
- End-stage renal disease and diabetes catalyze the formation of a pentose-derived crosslink from aging human collagen.
- Immunohistochemical detection of imidazolone, a novel advanced glycation end product, in kidneys and aortas of diabetic patients.
- Clearance of pentosidine, an advanced glycation end product, by different modalities of renal replacement therapy.
Cited by
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- Evaluation of Storage Conditions for Assessing DNA Damage Using the Comet Assay
- Secretory peptide hormones are biochemical antioxidants: structure-activity relationship.
- Smoking is associated with reduced serum levels of the antioxidant enzyme, paraoxonase, in Type 2 diabetic patients
- Agents in development for the treatment of diabetic nephropathy
- Up-regulation of advanced glycated products receptors in the brain of diabetic rats is prevented by antioxidant treatment.
- High-sensitivity C-reactive protein in Japanese patients with type 2 diabetes.
- Diabetic nephropathy: where hemodynamics meets metabolism.
- Oxidative stress evaluated using an automated method for hydroperoxide estimation in patients with coronary artery disease
- Effects of ginsenosides on organogenesis and expression of glutathione peroxidase genes in cultured rat embryos.
- Diabetes mellitus and cerebrovascular disease: which are the actual data?
- Amino acid supplements improve native antioxidant enzyme expression in the skeletal muscle of diabetic mice.
- Metabolism-induced oxidative stress is a mediator of glucose toxicity in HT22 neuronal cells
- Glutathione deficiency down-regulates hepatic lipogenesis in rats
- Evaluation of loganin, iridoid glycoside from Corni Fructus, on hepatic and renal glucolipotoxicity and inflammation in type 2 diabetic db/db mice.
- The therapeutic use of lipoic acid in diabetes: a current perspective.
- Below the radar: advanced glycation end products that detour "around the side". Is HbA1c not an accurate enough predictor of long term progression and glycaemic control in diabetes?
- High- and low-spin Fe(III) complexes of various AGE inhibitors.
- Effect of vitamin C supplementation on postprandial oxidative stress and lipid profile in type 2 diabetic patients.
- Effects of White Rice, Brown Rice and Germinated Brown Rice on Antioxidant Status of Type 2 Diabetic Rats
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