Interleukin 4 potently enhances murine macrophage mannose receptor activity: a marker of alternative immunologic macrophage activation
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Summary
Recombinant murine IL-4 is established as a potent and selective enhancer of murine MMR activity in vitro and induces inflammatory macrophages to adopt an alternative activation phenotype, distinct from that induced by IFN-gamma.
- Type
- article
- Published
- 1992-07-01
- Cited by
- 2,091
- References
- 21
- Access
- Open access
- OpenAlex
- https://openalex.org/W2123640179
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:7934935
Keywords
Mannose receptor, Molecular biology, Biology, Macrophage-activating factor, Tumor necrosis factor alpha
References
- Monomeric IgG2a promotes maturation of bone-marrow macrophages and expression of the mannose receptor.
- Priming the macrophage respiratory burst with IL-4: enhancement with TNF-alpha but inhibition by IFN-gamma.
- Alterations of surface properties by macrophage activation: expression of receptors for Fc and mannose-terminal glycoproteins and differentiation antigens.
- Influences of interleukins 2 and 4 on tumor necrosis factor production by murine mononuclear phagocytes.
- IL-4 inhibits the expression of IL-8 from stimulated human monocytes.
- IL-4 inhibits superoxide production by human mononuclear phagocytes.
- Differential regulation of class II MHC determinants on macrophages by IFN-gamma and IL-4.
- B cell stimulatory factor-1 (interleukin 4) activates macrophages for increased tumoricidal activity and expression of Ia antigens.
- IL-4 and granulocyte-macrophage colony-stimulating factor selectively increase HLA-DR and HLA-DP antigens but not HLA-DQ antigens on human monocytes.
- Receptor-mediated pinocytosis of mannose glycoconjugates by macrophages: characterization and evidence for receptor recycling.
- Interferon-gamma and B cell stimulatory factor-1 reciprocally regulate Ig isotype production.
- Cloning and expression in Escherichia coli of the cDNA for murine tumor necrosis factor.
- Interleukin 4 down‐regulates the expression of CD14 in normal human monocytes
- Mouse lysozyme M gene: isolation, characterization, and expression studies.
- Maintenance of granuloma macrophages in serum-free medium.
- Modulation of phenotypic and functional properties of human peripheral blood monocytes by IL-4.
- The macrophage mannose receptor: current status.
- Monoclonal antibody to the murine type 3 complement receptor inhibits adhesion of myelomonocytic cells in vitro and inflammatory cell recruitment in vivo
- Augmentation of glucocorticoid action on human monocytes by interleukin-4.
- Recombinant Interleukin-4 Enhances the Chemiluminescent Oxidative Burst of Murine Peritoneal Macrophages
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- Macrophage activation by T cells: cognate and non-cognate signals.
- Etude du rôle des sous-populations monocytaires dans l'obésité et l'insulinorésistance
- A Legumain-based minigene vaccine targets the tumor stroma and suppresses breast cancer growth and angiogenesis
- Myelin‐phagocytosing macrophages in isolated sciatic and optic nerves reveal a unique reactive phenotype
- Can the immune system be harnessed to repair the CNS?
- Hookworm-Induced Persistent Changes to the Immunological Environment of the Lung
- Alternative activation of tumor-associated macrophages by IL-4
- Classically and alternatively activated bone marrow derived macrophages differ in cytoskeletal functions and migration towards specific CNS cell types
- Glycoconjugates prevent B. anthracis toxin-induced cell death through binding while activating macrophages
- Induction of M2 regulatory macrophages through the β2 adrenergic receptor with protection during endotoxemia and acute lung injury
- Role of IL-4 Gene Polymorphisms in HBV-Related Hepatocellular Carcinoma in a Chinese Population
- Are “Resting” Microglia More “M2”?
- Endocannabinoids drive the acquisition of an alternative phenotype in microglia.
- IL-4 Expression Delays Eosinophil-Independent Vasculopathy and Fibrosis During Allograft Rejection in the Mouse
- Neuroinflammation: The Devil is in the Details
- Macrophage fusion and multinucleated giant cells of inflammation.
- Dual polarization of human alveolar macrophages progressively increases with smoking and COPD severity
- Recruited monocytes and Th2 cytokine signaling promote lung regeneration following pneumonectomy
- Anti-Inflammatory Targets for the Treatment of Reperfusion Injury in Stroke
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