The cancer genome
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Summary
This work has shown that the complete DNA sequence of large numbers of cancer genomes will be possible to obtain and will provide a detailed and comprehensive perspective on how individual cancers have developed.
- Type
- review
- Published
- 2009-04-09
- Cited by
- 3,650
- References
- 69
- Access
- Open access
- OpenAlex
- https://openalex.org/W2059300459
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:13781831
Keywords
Genome, Human genome, Cancer, Sequence (biology), Biology
References
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- Patterns of somatic mutation in human cancer genomes
- Somatic mutations of the histone H3K27 demethylase, UTX, in human cancer
- Comprehensive genomic characterization defines human glioblastoma genes and core pathways
- Several types of mutations of the Abl gene can be found in chronic myeloid leukemia patients resistant to STI571, and they can pre-exist to the onset of treatment.
- Cancers exhibit a mutator phenotype: clinical implications.
Cited by
- The Impracticality of Biomedical Rejuvenation Therapies: Translational and Pharmacological Barriers
- The use of DNA transposons for cancer gene discovery in mice.
- Genetic characterization of breast cancer and implications for clinical management
- Human variation databases
- Colorectal cancer: cetuximab, KRAS, BRAF, PIK3CA mutations and beyond
- Deep RNA sequencing analysis of readthrough gene fusions in human prostate adenocarcinoma and reference samples
- Innovative technology for cancer risk analysis.
- Targeting the cell cycle in esophageal adenocarcinoma: an adjunct to anticancer treatment.
- Remarkable difference of somatic mutation patterns between oncogenes and tumor suppressor genes.
- Urothelial carcinoma of the bladder: definition, treatment and future efforts
- Loss of giant obscurins promotes breast epithelial cell survival through apoptotic resistance
- Genomic instability at the 13q31 locus and somatic mtDNA mutation in the D-loop site correlate with tumor aggressiveness in sporadic Brazilian breast cancer cases
- Electroanalysis of single-nucleotide polymorphism by hairpin DNA architectures
- Review of mass spectrometry-based metabolomics in cancer research
- Embryonic left–right separation mechanism allows confinement of mutation‐induced phenotypes to one lateral body half of bilaterians
- Acute myeloid leukemia with DNMT3A mutations
- Target genes discovery through copy number alteration analysis in human hepatocellular carcinoma.
- Molecular Heterogeneity of Glioblastoma and its Clinical Relevance
- ContrastRank: a new method for ranking putative cancer driver genes and classification of tumor samples
- Beyond Mutations: Additional Mechanisms and Implications of SWI/SNF Complex Inactivation
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