Sodium taurocholate cotransporting polypeptide is a functional receptor for human hepatitis B and D virus
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Summary
It is shown that the receptor-binding region of pre-S1 specifically interacts with sodium taurocholate cotransporting polypeptide (NTCP), a multiple transmembrane transporter predominantly expressed in the liver that is a functional receptor for HBV and HDV.
- Type
- article
- Published
- 2012-11-13
- Cited by
- 1,960
- References
- 65
- Access
- Open access
- OpenAlex
- https://openalex.org/W2120426460
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:2031996
Keywords
Virology, Hepatitis B virus, Receptor, Viral entry, Biology
References
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- Infection of a human hepatoma cell line by hepatitis B virus
- The role of the sodium-taurocholate cotransporting polypeptide (NTCP) and of the bile salt export pump (BSEP) in physiology and pathophysiology of bile formation.
- Topography of the membrane domain of the liver Na+-dependent bile acid transporter.
- Characterization of a hepatitis B and hepatitis delta virus receptor binding site
- Crystal structure of a bacterial homologue of the bile acid sodium symporter ASBT
- Efficient Inhibition of Hepatitis B Virus Infection by Acylated Peptides Derived from the Large Viral Surface Protein
- Photo-leucine and photo-methionine allow identification of protein-protein interactions in living cells
- DTASelect and Contrast: tools for assembling and comparing protein identifications from shotgun proteomics.
- In-gel digestion for mass spectrometric characterization of proteins and proteomes
- FFAS03: a server for profile–profile sequence alignments
- Analysis of Host Range Phenotypes of Primate Hepadnaviruses by In Vitro Infections of Hepatitis D Virus Pseudotypes
- Structure and replication of the genome of hepatitis delta virus.
- Analysis of the Cytosolic Domains of the Hepatitis B Virus Envelope Proteins for Their Function in Viral Particle Assembly and Infectivity
- Chlorambucil-taurocholate is transported by bile acid carriers expressed in human hepatocellular carcinomas.
- Myristylation of the hepatitis B virus large surface protein is essential for viral infectivity.
Cited by
- Antihepatitis B therapy: a review of current medications and novel small molecule inhibitors
- HBV life cycle is restricted in mouse hepatocytes expressing human NTCP
- Hepatitis B: future curative strategies
- MicroRNA-130a can inhibit hepatitis B virus replication via targeting PGC1α and PPARγ
- Hepatitis D Virus Infection of Mice Expressing Human Sodium Taurocholate Co-transporting Polypeptide
- Hepatitis B virus antigens impair NK cell function.
- HBV therapeutic vaccines and cccDNA inhibitors – emergence of a cure
- Antiviral therapy of hepatitis delta virus infection - progress and challenges towards cure.
- A potent human neutralizing antibody Fc-dependently reduces established HBV infections
- Advanced Strategies for Eliminating the cccDNA of HBV
- The Hepatitis B Surface Antigen Binding Protein: An Immunoglobulin G Constant Region-Like Protein That Interacts With HBV Envelop Proteins and Mediates HBV Entry
- Cellular DNA Topoisomerases Are Required for the Synthesis of Hepatitis B Virus Covalently Closed Circular DNA
- Recent advances in use of gene therapy to treat hepatitis B virus infection.
- Rational Basis for Optimizing Short and Long-term Hepatitis B Virus Prophylaxis Post Liver Transplantation: Role of Hepatitis B Immune Globulin
- Spinoculation Enhances HBV Infection in NTCP-Reconstituted Hepatocytes
- Chronic hepatitis B: Virology, natural history, current management and a glimpse at future opportunities.
- Irbesartan, an FDA approved drug for hypertension and diabetic nephropathy, is a potent inhibitor for hepatitis B virus entry by disturbing Na(+)-dependent taurocholate cotransporting polypeptide activity.
- Variabilité du virus de l'hépatite B
- Intracellular trafficking of bio-nanocapsule-liposome complex: Identification of fusogenic activity in the pre-S1 region of hepatitis B virus surface antigen L protein.
- Current and future directions for treating hepatitis B virus infection.
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