Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
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Summary
This review will focus on the role of the main cytokines, chemokines, and their receptors in the pathophysiology of auto-inflammatory disorders, pro- inflammatory disorders, and neurological disorders involving inflammation.
- Type
- review
- Published
- 2014-11-01
- Cited by
- 1,954
- References
- 339
- Access
- Open access
- OpenAlex
- https://openalex.org/W2118742454
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:37398988
Keywords
Chemokine, Inflammation, Immunology, Immune system, Cytokine
References
- A domain in TNF receptors that mediates ligand-independent receptor assembly and signaling.
- nNOS expression in reactive astrocytes correlates with increased cell death related DNA damage in the hippocampus and entorhinal cortex in Alzheimer's disease.
- Neuroimmunophilin ligands in the treatment of Parkinson's disease.
- Involvement of inducible nitric oxide synthase in inflammation-induced dopaminergic neurodegeneration.
- Role of chemokines and chemokine receptors in regulating specific leukocyte trafficking in the immune/inflammatory response.
- Roles for NF-κB in nerve cell survival, plasticity, and disease
- SPPL2a and SPPL2b promote intramembrane proteolysis of TNFα in activated dendritic cells to trigger IL-12 production
- Adult neurogenesis, neuroinflammation and therapeutic potential of adult neural stem cells
- Interleukin-1 Receptor Type 1 Is a Substrate for γ-Secretase-dependent Regulated Intramembrane Proteolysis*
- IL-1 and T Helper Immune Responses
- Serum and urinary cytokine levels of SLE patients.
- A novel mutation in the CIAS1/NLRP3 gene associated with an unexpected phenotype of cryopyrin-associated periodic syndromes.
- Familial Hibernian fever.
- Virus interference. I. The interferon
- Transgenic mice expressing human tumour necrosis factor: a predictive genetic model of arthritis.
- Inflammation and infection in Parkinson's disease.
- Signaling via NF-kappaB in the nervous system.
- Interleukin-6 and soluble interleukin-6 receptor: direct stimulation of gp130 and hematopoiesis.
- Hematopoietic-specific expression of MEFV, the gene mutated in familial Mediterranean fever, and subcellular localization of its corresponding protein, pyrin.
- Accumulated Amyloid-β Peptide and Hyperphosphorylated Tau Protein: Relationship and Links in Alzheimer's Disease
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- Intracellular TLR7 is activated in human oligodendrocytes in response to Borrelia burgdorferi exposure
- Vitamin D pathway activation selectively deactivates signal transducer and activator of transcription (STAT) proteins and inflammatory cytokine production in natural killer leukemic large granular lymphocytes
- Flavonoids are identified from the extract of Scutellariae Radix to suppress inflammatory-induced angiogenic responses in cultured RAW 264.7 macrophages
- Intravenous anesthetic ketamine attenuates complete Freund’s adjuvant-induced arthritis in rats via modulation of MAPKs/NF-κB
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- IL-17 signaling components in bivalves: Comparative sequence analysis and involvement in the immune responses.
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- Opposite Expression of SPARC between the Liver and Pancreas in Streptozotocin-Induced Diabetic Rats
- Cytokine and Antioxidant Regulation in the Intestine of the Gray Mouse Lemur (Microcebus murinus) During Torpor
- Evidence of Perturbations of the Cytokine Network in Preterm Labor
- Claudin-3 is required for modulation of paracellular permeability by TNF-α through ERK1/2/slug signaling axis in submandibular gland.
- Sodium Hydrosulfide Exerts a Transitional Attenuating Effect on Spermatozoa Migration in Vitro.
- Mechanisms of Biomaterial-Mediated Cardiac and Esophageal Repair
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