nNOS expression in reactive astrocytes correlates with increased cell death related DNA damage in the hippocampus and entorhinal cortex in Alzheimer's disease.
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Summary
The results imply that an upregulated production of NO by reactive astrocytes may play a key role in the pathogenesis of AD.
- Type
- article
- Published
- 2000-09-01
- Cited by
- 123
- References
- 72
- OpenAlex
- https://openalex.org/W10964481
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:10128019
Keywords
Computer science, Psychology
References
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- NMDA and Kainate Induce Internucleosomal DNA Cleavage Associated With Both Apoptotic and Necrotic Cell Death in the Neonatal Rat Brain
- DNA fragmentation in human substantia nigra: Apoptosis or perimortem effect?
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- Astroglial cell subtypes in the cerebella of normal adults, elderly adults, and patients with Alzheimer's disease: A histological and immunohistochemical comparison
- Differential Requirements for l-Citrulline and l-Arginine during Antimycobacterial Macrophage Activity
- Endothelial nitric oxide deficiency promotes Alzheimer’s disease pathology
- The role of inflammation in Alzheimer's disease.
- Differential Neuroprotective Properties of Endogenous and Exogenous Erythropoietin in a Mouse Model of Traumatic Brain Injury
- Neuronal nitric oxide synthase: structure, subcellular localization, regulation, and clinical implications.
- STIMULATED MICROGLIA SUPERNATANTS INDUCED OVEREXPRESSION OF NEURONAL NITRIC OXIDE GENE IN ASTROCYTES
- Analysis of microdissected neurons by 18O mass spectrometry reveals altered protein expression in Alzheimer's disease
- Intact spatial memory in mice with seizure-induced partial loss of hippocampal pyramidal neurons.
- Epigallocatechin-3-gallate prevents systemic inflammation-induced memory deficiency and amyloidogenesis via its anti-neuroinflammatory properties.
- Effects of cyclooxygenase inhibitor pretreatment on nitric oxide production, nNOS and iNOS expression in rat cerebellum
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