Cyclic Nucleotide Phosphodiesterases: Molecular Regulation to Clinical Use
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Summary
Basic biochemical properties, cellular regulation, expression patterns, and physiological functions of the different PDE isoforms will be discussed and how these properties relate to the current and future development of PDE inhibitors as pharmacological agents is especially considered.
- Type
- review
- Published
- 2006-09-01
- Cited by
- 1,789
- References
- 287
- OpenAlex
- https://openalex.org/W2118462346
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:7397281
Keywords
Vardenafil, Tadalafil, Phosphodiesterase, Cyclic nucleotide, Isozyme
References
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- Assay of cyclic nucleotide phosphodiesterase and resolution of multiple molecular forms of the enzyme.
- Identification and characterization of a new human type 9 cGMP-specific phosphodiesterase splice variant (PDE9A5). Differential tissue distribution and subcellular localization of PDE9A variants.
- Generation of PDE4 knockout mice by gene targeting.
- Purification of calmodulin-stimulated cyclic nucleotide phosphodiesterase by monoclonal antibody affinity chromatography.
- Molecular properties of mammalian proteins that interact with cGMP: protein kinases, cation channels, phosphodiesterases, and multi-drug anion transporters.
- 血小板のcyclic nucleotide (血小板)
- Calmodulin and signal transduction
- Isolation and characterization
- Characterization of a novel cGMP binding protein from rat lung.
- Genomic organization of the human phosphodiesterase PDE11A gene. Evolutionary relatedness with other PDEs containing GAF domains.
- Cyclic GMP as substrate and regulator of cyclic nucleotide phosphodiesterases (PDEs).
- Pharmacokinetic and pharmacodynamic profile following oral administration of the phosphodiesterase (PDE)4 inhibitor V11294A in healthy volunteers.
- Isolation and characterization of a previously undetected human cAMP phosphodiesterase by complementation of cAMP phosphodiesterase-deficient Saccharomyces cerevisiae.
- A-Kinase Anchoring Proteins Interact with Phosphodiesterases in T Lymphocyte Cell Lines1
- Sildenafil citrate increases myocardial cGMP content in rat heart, decreases its hypertrophic response to isoproterenol and decreases myocardial leak of creatine kinase and troponin T
- Striatum- and testis-specific phosphodiesterase PDE10A isolation and characterization of a rat PDE10A.
- TCR- and CD28-Mediated Recruitment of Phosphodiesterase 4 to Lipid Rafts Potentiates TCR Signaling1
Cited by
- Fosfodiesterasas del AMPc y del GMPc en el cerebro: Expresión en procesos neuroinflamatorios y neurodegenerativos
- Inhibition of cyclic nucleotide phosphodiesterases by methylxanthines and related compounds.
- Targeting Phosphodiesterases in Anti-platelet Therapy
- Constitutive Phosphodiesterase Activity Restricts Spontaneous Beating Rate of Cardiac Pacemaker Cells by Suppressing Local Ca2+ Releases
- Phosphodiesterases in the central nervous system.
- The role of calcium in the regulation of renin secretion.
- Sildenafil protects against 3-nitropropionic acid neurotoxicity through the modulation of calpain, CREB, and BDNF.
- Myocardial and Reproductive System Toxicity of SCH 351591, a Selective Phosphodiesterase-4 Inhibitor, in CD-1 Mice
- Absence of MSY2 in Mouse Oocytes Perturbs Oocyte Growth and Maturation, RNA Stability, and the Transcriptome1
- The GAF-tandem domain of phosphodiesterase 5 as a potential drug target.
- Effect of vardenafil on semen parameters in infertile men: A pilot study evaluating short-term treatment
- Intramolecular signaling in tandem-GAF domains from PDE5 and PDE10 studied with a cyanobacterial adenylyl cyclase reporter.
- Potential therapeutic applications of phosphodiesterase inhibition in prostate cancer
- Newer agents in antiplatelet therapy: a review
- Cellular Targets of Nitric Oxide in the Hippocampus
- Differential regulation of cardiac excitation-contraction coupling by cAMP phosphodiesterase subtypes.
- The Role of Cyclic Nucleotide Signaling Pathways in Cancer: Targets for Prevention and Treatment
- Zaprinast impairs spatial memory by increasing PDE5 expression in the rat hippocampus.
- Development of computational models of cAMP signaling.
- Inhibition of breast cancer cell migration by activation of cAMP signaling
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