Zaprinast impairs spatial memory by increasing PDE5 expression in the rat hippocampus.
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Summary
The effect of post-training intraperitoneal administration of zaprinast on rat memory retention in the Morris water maze task that revealed a significant memory impairment at the intermediate dose of 10mg/kg is reported.
- Type
- article
- Published
- 2015-02-01
- Cited by
- 8
- References
- 60
- OpenAlex
- https://openalex.org/W25281278
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:21395170
Keywords
Computer science, Philosophy
References
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- Review: Modulation of striatal neuron activity by cyclic nucleotide signaling and phosphodiesterase inhibition
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- Role of guanylyl cyclase and cGMP-dependent protein kinase in long-term potentiation
Cited by
- Use of the KlADH3 promoter for the quantitative production of the murine PDE5A isoforms in the yeast Kluyveromyces lactis
- The oligomeric assembly of the phosphodiesterase-5 is a mixture of dimers and tetramers: A putative role in the regulation of function.
- Metabolic role of cGMP in S. cerevisiae: the murine phosphodiesterase-5 activity affects yeast cell proliferation by altering the cAMP/cGMP equilibrium.
- Cellular Redox Metabolism Is Modulated by the Distinct Localization of Cyclic Nucleotide Phosphodiesterase 5A Isoforms
- Avanafil mediated dual inhibition of IKKβ and TNFR1 in an experimental paradigm of Alzheimer’s disease: in silico and in vivo approach
- Structural Characterization of Murine Phosphodiesterase 5 Isoforms and Involvement of Cysteine Residues in Supramolecular Assembly
- Hippocampal GPR35 Participates in the Pathogenesis of Cognitive Deficits and Emotional Alterations Induced by Aβ1–42 in Mice
- Hippocampal GPR35 is involved in the depression-like behaviors induced by inflammation and mediates the antidepressant effects of fluoxetine in mice.
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