Differential regulation of cardiac excitation-contraction coupling by cAMP phosphodiesterase subtypes.
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Summary
It is demonstrated that PDE2 and PDE3 play a more prominent role than PDE4 in regulating basal cardiac contraction and Ca(2+) transients and Pde4 becomes determinant when cAMP levels are elevated, for instance, upon β-adrenergic stimulation or Pde3 inhibition.
- Type
- article
- Published
- 2013-11-01
- Cited by
- 57
- References
- 63
- Access
- Open access
- OpenAlex
- https://openalex.org/W2096227816
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:24983851
Keywords
Phosphodiesterase, Excitation–contraction coupling, Contraction (grammar), Internal medicine, Phosphodiesterase 3
References
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- Conserved expression and functions of PDE4 in rodent and human heart
- Cyclic Nucleotide Phosphodiesterases in Health and Disease
- Modulation of excitation–contraction coupling by isoproterenol in cardiomyocytes with controlled SR Ca2+ load and Ca2+ current trigger
- Regulation and function of the cyclic nucleotide phosphodiesterase (PDE3) gene family.
- Effect of milrinone on left ventricular relaxation and Ca(2+) uptake function of cardiac sarcoplasmic reticulum.
- Erythro-9-(2-hydroxy-3-nonyl)adenine inhibits cyclic GMP-stimulated phosphodiesterase in isolated cardiac myocytes.
- Involvement of Rolipram-Sensitive Cyclic AMP Phosphodiesterase in the Regulation of Cardiac Contraction
- Cyclic AMP‐mediated regulation of vascular smooth muscle cell cyclic AMP phosphodiesterase activity
- Differential Sensitivity to Cardiotonic Drugs of Cyclic AMP Phosphodiesterases Isolated from Canine Ventricular and Sinoatrial‐Enriched Tissues
- Contribution of phosphodiesterase isozymes to the regulation of the L‐type calcium current in human cardiac myocytes
- PDEs create local domains of cAMP signaling.
- PI3K&ggr; Is Required for PDE4, not PDE3, Activity in Subcellular Microdomains Containing the Sarcoplasmic Reticular Calcium ATPase in Cardiomyocytes
- A Specific Pattern of Phosphodiesterases Controls the cAMP Signals Generated by Different Gs-Coupled Receptors in Adult Rat Ventricular Myocytes
- Cyclic nucleotide phosphodiesterase (PDE) superfamily: a new target for the development of specific therapeutic agents.
- Beta-adrenergic receptor agonists and cyclic nucleotide phosphodiesterase inhibitors: shifting the focus from inotropy to cyclic adenosine monophosphate.
- Differential effects of Ro 20-1724 and isobutylmethylxanthine on the basal force of contraction and beta-adrenoceptor-mediated response in the rat ventricular myocardium.
- Spatiotemporal Dynamics of β-Adrenergic cAMP Signals and L-Type Ca2+ Channel Regulation in Adult Rat Ventricular Myocytes: Role of Phosphodiesterases
- Myocardial Phosphodiesterases and Regulation of Cardiac Contractility in Health and Cardiac Disease
- β-Adrenergic receptor signaling in the heart: Role of CaMKII
Cited by
- Pharmacological targeting of AKAP-directed compartmentalized cAMP signalling.
- Contribution des phosphodiestérases 3 et 4 au maintien de l’homéostasie calcique et à la prévention des arythmies ventriculaires dans le cardiomyocyte adulte
- Sex differences in SR Ca(2+) release in murine ventricular myocytes are regulated by the cAMP/PKA pathway.
- Cyclic AMP synthesis and hydrolysis in the normal and failing heart
- Targeting the sarcomere to correct muscle function
- PDE4B mediates local feedback regulation of &bgr;1-adrenergic cAMP signaling in a sarcolemmal compartment of cardiac myocytes
- Correlation between endogenous polyamines in human cardiac tissues and clinical parameters in patients with heart failure
- AKAP150 participates in calcineurin/NFAT activation during the down-regulation of voltage-gated K+ currents in ventricular myocytes following myocardial infarction
- Calmodulin kinase II inhibition limits the pro-arrhythmic Ca2+ waves induced by cAMP-phosphodiesterase inhibitors.
- PHOSPHODIESTERASE: WHAT IS IN AN ENZYME?
- Epac proteins: specific ligands and role in cardiac remodelling.
- The impact of estrogen and the cAMP/PKA pathway on male-female differences in SR calcium release in murine cardiomyocytes
- Cardiac Phosphodiesterases and their Modulation for Treating Heart Disease
- Roflumilast and aquaporin‐2 regulation in rat renal inner medullary collecting duct
- Heterologous desensitization of cardiac &bgr;-adrenergic signal via hormone-induced &bgr;AR/arrestin/PDE4 complexes
- Remodelling of the cardiac caveolar domain in heart failure and its putative influence on beta adrenergic signalling
- PDE2 at the crossway between cAMP and cGMP signalling in the heart.
- Standard and Strain Measurements by Echocardiography Detect Early Overloaded Right Ventricular Dysfunction: Validation against Hemodynamic and Myocyte Contractility Changes in a Large Animal Model
- Cyclic AMP signaling in cardiac myocytes
- Basal Spontaneous Firing of Rabbit Sinoatrial Node Cells is Regulated by Dual Phosphodiesterase 3 and 4 Activation
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