Role of nrf2 in oxidative stress and toxicity.
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Summary
The nuclear factor erythroid 2-related factor 2 (Nrf2) is an emerging regulator of cellular resistance to oxidants that controls the basal and induced expression of an array of antioxidant response element-dependent genes to regulate the physiological and pathophysiological outcomes of oxidant exposure.
- Type
- review
- Published
- 2013-01-07
- Cited by
- 4,527
- References
- 171
- Access
- Open access
- OpenAlex
- https://openalex.org/W2117800935
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:25543354
Keywords
Oxidative stress, Reactive oxygen species, Antioxidant, Cell biology, Signal transduction
References
- Phosphorylation of Nrf2 at Ser-40 by Protein Kinase C Regulates Antioxidant Response Element-mediated Transcription*
- Keap1 Is a Redox-Regulated Substrate Adaptor Protein for a Cul3-Dependent Ubiquitin Ligase Complex
- Signal integration in the endoplasmic reticulum unfolded protein response
- Oxidative Stress and Alcoholic Liver Disease
- A Noncanonical Mechanism of Nrf2 Activation by Autophagy Deficiency: Direct Interaction between Keap1 and p62
- The antioxidant responsive element. Activation by oxidative stress and identification of the DNA consensus sequence required for functional activity.
- Chemical structures of inducers of nicotinamide quinone oxidoreductase 1 (NQO1).
- Transcriptional regulation of the rat NAD(P)H:quinone reductase gene. Identification of regulatory elements controlling basal level expression and inducible expression by planar aromatic compounds and phenolic antioxidants.
- Molecular mechanisms of the Keap1–Nrf2 pathway in stress response and cancer evolution
- Transcriptional regulation of the rat glutathione S-transferase Ya subunit gene. Characterization of a xenobiotic-responsive element controlling inducible expression by phenolic antioxidants.
- Dietary effects on cytochromes P450, xenobiotic metabolism, and toxicity
- Protection against Chromium (VI)‐induced oxidative stress and apoptosis by Nrf2. recruiting Nrf2 into the nucleus and disrupting the nuclear Nrf2/Keap1 association by toxic metal
- Inhibition of carcinogenic and toxic effects of polycyclic hydrocarbons by phenolic antioxidants and ethoxyquin.
- Nrf2 the Rescue: Effects of the Antioxidative/Electrophilic Response on the Liver
- Keap1 perceives stress via three sensors for the endogenous signaling molecules nitric oxide, zinc, and alkenals
- Targeted disruption of Nrf2 causes regenerative immune-mediated hemolytic anemia.
- Xenobiotic-inducible expression of murine glutathione S-transferase Ya subunit gene is controlled by an electrophile-responsive element.
- Mammalian thioredoxin is a direct inhibitor of apoptosis signal‐regulating kinase (ASK) 1
- Nrf1 and Nrf2 positively and c-Fos and Fra1 negatively regulate the human antioxidant response element-mediated expression of NAD(P)H:quinone oxidoreductase1 gene.
- CDDO-Im Protects from Acetaminophen Hepatotoxicity Through Induction of Nrf2-Dependent Genes
Cited by
- Tanshinone II A Inhibits Tat‐Induced HIV‐1 Transactivation Through Redox‐Regulated AMPK/Nampt Pathway
- Conditioned Media of Choroid Plexus Epithelial Cells Induces Nrf2-Activated Phase II Antioxidant Response Proteins and Suppresses Oxidative Stress-Induced Apoptosis in PC12 Cells
- Adoptive Transfer of Heme Oxygenase-1 (HO-1)-Modified Macrophages Rescues the Nuclear Factor Erythroid 2-Related Factor (Nrf2) Antiinflammatory Phenotype in Liver Ischemia/Reperfusion Injury
- Quercetin Metabolites Up‐Regulate the Antioxidant Response in Osteoblasts Isolated From Fetal Rat Calvaria
- Nrf2 Activation Inhibits Effects of Thrombin in Human Amnion Cells and Thrombin-Induced Preterm Birth in Mice.
- Inorganic Arsenic Induces NRF2-Regulated Antioxidant Defenses in Both Cerebral Cortex and Hippocampus in Vivo
- Discovery, Synthesis, and Functional Characterization of a Novel Neuroprotective Natural Product from the Fruit of Alpinia oxyphylla for use in Parkinson's Disease Through LC/MS-Based Multivariate Data Analysis-Guided Fractionation.
- Asiatic acid enhances Nrf2 signaling to protect HepG2 cells from oxidative damage through Akt and ERK activation.
- The ROS-mediated pathway coupled with the MAPK-p38 signalling pathway and antioxidant system plays roles in the responses of Mytilus edulis haemocytes induced by BDE-47.
- Nuclear factor E2-related factor 2 knockdown enhances glucose uptake and alters glucose metabolism in AML12 hepatocytes
- Aldose Reductase Inhibitor Protects against Hyperglycemic Stress by Activating Nrf2-Dependent Antioxidant Proteins
- Serum Iron Protects from Renal Postischemic Injury.
- Fine chalk dust induces inflammatory response via p38 and ERK MAPK pathway in rat lung
- Adrenergic regulation during acute hepatic infection with Entamoeba histolytica in the hamster: involvement of oxidative stress, Nrf2 and NF-KappaB
- Antioxidant Properties of Buffalo-Milk Dairy Products: A β-Lg Peptide Released after Gastrointestinal Digestion of Buffalo Ricotta Cheese Reduces Oxidative Stress in Intestinal Epithelial Cells
- Hydrogen peroxide modulates redox status, energy metabolism, and gene expression in a dose‐ and time‐dependent manner in rat liver
- Pro- and antitumor effects of mitochondrial reactive oxygen species
- Nrf2–Keap1 pathway–mediated effects of resveratrol on oxidative stress and apoptosis in hydrogen peroxide–treated rheumatoid arthritis fibroblast‐like synoviocytes
- Ginger and turmeric lipid-solubles attenuate heated oil-induced oxidative stress in the brain via the upregulation of NRF2 and improve cognitive function in rats
- Decorated Polyetheretherketone Implants with Antibacterial and Antioxidative Effects through Layer-by-Layer Nanoarchitectonics Facilitate Diabetic Bone Integration with Infection.
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