Protection against Chromium (VI)‐induced oxidative stress and apoptosis by Nrf2. recruiting Nrf2 into the nucleus and disrupting the nuclear Nrf2/Keap1 association by toxic metal

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Summary

Protection against Cr(VI) toxicity involves a transcriptional signaling loop that includes activation of Nrf2 signaling by toxic metal, transcription of ARE‐driven genes, and reduction of ROS production.

Type
article
Published
2007-04-01
Cited by
110
References
39
Access
Open access

Keywords

KEAP1, Oxidative stress, Reactive oxygen species, Chemistry, Apoptosis

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