Protection against Chromium (VI)‐induced oxidative stress and apoptosis by Nrf2. recruiting Nrf2 into the nucleus and disrupting the nuclear Nrf2/Keap1 association by toxic metal
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Summary
Protection against Cr(VI) toxicity involves a transcriptional signaling loop that includes activation of Nrf2 signaling by toxic metal, transcription of ARE‐driven genes, and reduction of ROS production.
- Type
- article
- Published
- 2007-04-01
- Cited by
- 110
- References
- 39
- Access
- Open access
- OpenAlex
- https://openalex.org/W1932294180
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:726945
Keywords
KEAP1, Oxidative stress, Reactive oxygen species, Chemistry, Apoptosis
References
- Keap1 Is a Redox-Regulated Substrate Adaptor Protein for a Cul3-Dependent Ubiquitin Ligase Complex
- The pathways and molecular mechanisms regulating Nrf2 activation in response to chemical stress.
- Integration and diversity of the regulatory network composed of Maf and CNC families of transcription factors.
- Deficiency of the Nrf1 and Nrf2 Transcription Factors Results in Early Embryonic Lethality and Severe Oxidative Stress*
- Direct measurement of NAD(P)H:quinone reductase from cells cultured in microtiter wells: a screening assay for anticarcinogenic enzyme inducers.
- Neurons Overexpressing Heme Oxygenase‐1 Resist Oxidative Stress‐Mediated Cell Death
- Nrf2 Controls Constitutive and Inducible Expression of ARE-driven Genes through a Dynamic Pathway Involving Nucleocytoplasmic Shuttling by Keap1*
- Specific Patterns of Electrophile Adduction Trigger Keap1 Ubiquitination and Nrf2 Activation*
- In Vivo Role of NAD(P)H:Quinone Oxidoreductase 1 (NQO1) in the Regulation of Intracellular Redox State and Accumulation of Abdominal Adipose Tissue*
- Superinduction of CYP1A1 Gene Expression
- The elusive function of metallothioneins.
- Role of hypoxia-induced Bax translocation and cytochrome c release in reoxygenation injury
- Multiorgan autoimmune inflammation, enhanced lymphoproliferation, and impaired homeostasis of reactive oxygen species in mice lacking the antioxidant-activated transcription factor Nrf2.
- Cultured astrocytes from heme oxygenase‐1 knockout mice are more vulnerable to heme‐mediated oxidative injury
- Origins of individual variability in P4501A induction.
- Use of genetically modified mouse models to assess pathways of benzene-induced bone marrow cytotoxicity and genotoxicity.
- An important function of Nrf2 in combating oxidative stress: Detoxification of acetaminophen
- Antibody-induced transplant arteriosclerosis is prevented by graft expression of anti-oxidant and anti-apoptotic genes
- The Effect of Inhaled Chromium on Different Exhaled Breath Condensate Biomarkers among Chrome-Plating Workers
- Chromium(VI) Down-regulates Heavy Metal-induced Metallothionein Gene Transcription by Modifying Transactivation Potential of the Key Transcription Factor, Metal-responsive Transcription Factor 1*
Cited by
- Effects of atmospheric pollutants on the Nrf2 survival pathway
- The effects of chromium(VI) on the thioredoxin system: Implications for redox regulation
- The Janus Face of the Heme Oxygenase/Biliverdin Reductase System in Alzheimer Disease: It’s Time for Reconciliation
- Review of molecular mechanisms involved in the activation of the Nrf2-ARE signaling pathway by chemopreventive agents.
- The response to chemical stress: development of preclinical and translational biomarkers of Nrf2 activity
- Sulforaphane protects against ethanol‐induced oxidative stress and apoptosis in neural crest cells by the induction of Nrf2‐mediated antioxidant response
- The Developmental and Physiological Interactions between Free Radicals and Antioxidant Defense System: Effect of Environmental Pollutants
- Metals and apoptosis: recent developments.
- Chromium (VI)‐induced oxidative stress and apoptosis is reduced by garlic and its derivative S‐allylcysteine through the activation of Nrf2 in the hepatocytes of Wistar rats
- NRF2 Oxidative Stress Induced by Heavy Metals is Cell Type Dependent
- Molecular mechanisms of natural products in chemoprevention: induction of cytoprotective enzymes by Nrf2.
- Activation of Nrf2 by cadmium and its role in protection against cadmium-induced apoptosis in rat kidney cells.
- Over-expression of Nrf2 diminishes ethanol-induced oxidative stress and apoptosis in neural crest cells by inducing an antioxidant response
- The prospective protective effect of selenium nanoparticles against chromium-induced oxidative and cellular damage in rat thyroid
- Protective effects of phenolic constituents from Cytisus multiflorus, Lamium album L. and Thymus citriodorus on liver cells
- The cap'n'collar transcription factor Nrf2 mediates both intrinsic resistance to environmental stressors and an adaptive response elicited by chemopreventive agents that determines susceptibility to electrophilic xenobiotics.
- Induction of Metallothionein I by Arsenic via Metal-activated Transcription Factor 1
- Nrf2-Mediated Transcriptional Induction of Antioxidant Response in Mouse Embryos Exposed to Ethanol in vivo: Implications for the Prevention of Fetal Alcohol Spectrum Disorders
- Oxidative stress and oxidative damage in chemical carcinogenesis.
- Transgenic Mice Overexpressing Methionine Sulfoxide Reductase A: Characterization of Embryonic Fibroblasts
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