Cancer epigenetics: from mechanism to therapy.
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Summary
The basic principles behind DNA methylation, histone modification, nucleosome remodeling, and RNA-mediated targeting are presented and the evidence suggesting that their misregulation can culminate in cancer is highlighted.
- Type
- review
- Published
- 2012-07-06
- Cited by
- 3,042
- References
- 139
- Access
- Open access
- OpenAlex
- https://openalex.org/W2117247812
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:13905699
Keywords
Epigenetics, Biology, Chromatin, Histone, DNA methylation
References
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- The MMSET protein is a histone methyltransferase with characteristics of a transcriptional corepressor.
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Cited by
- Genetic Alterations in Pheochromocytoma and Paraganglioma
- [Models of oncogenesis: an endless world?].
- An epigenetic framework for neurodevelopmental disorders: from pathogenesis to potential therapy.
- Tet1 is required for Rb phosphorylation during G1/S phase transition.
- Why is epigenetics important in understanding the pathogenesis of inflammatory musculoskeletal diseases?
- Cross-talk among epigenetic modifications: lessons from histone arginine methylation.
- The transcription factor FOXM1 (Forkhead box M1): proliferation-specific expression, transcription factor function, target genes, mouse models, and normal biological roles.
- Genomics and epigenomics: new promises of personalized medicine for cancer patients.
- Epithelial cancers in the post-genomic era: should we reconsider our lifestyle?
- The chromatin remodelling component SMARCB1/INI1 influences the metastatic behavior of colorectal cancer through a gene signature mapping to chromosome 22
- Minfi: a flexible and comprehensive Bioconductor package for the analysis of Infinium DNA methylation microarrays
- Secreted phospholipases A₂are differentially expressed and epigenetically silenced in human breast cancer cells.
- Oncometabolites‐driven tumorigenesis: From genetics to targeted therapy
- Histone Methyltransferase Inhibitors Are Orally Bioavailable, Fast-Acting Molecules with Activity against Different Species Causing Malaria in Humans
- New Developments in the Pathogenesis and Therapeutic Targeting of the IDH1 Mutation in Glioma
- Epigenetic regulation of active Chinese herbal components for cancer prevention and treatment: A follow-up review.
- Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study
- Dietary phytochemical PEITC restricts tumor development via modulation of epigenetic writers and erasers
- DNA methyltransferases and their roles in tumorigenesis
- EMT, CSCs, and drug resistance: the mechanistic link and clinical implications
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