Prothymosin α variants isolated from CD8+ T cells and cervicovaginal fluid suppress HIV-1 replication through type I interferon induction.
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Summary
The isolation and identification of 2 new ProTα variants from CD8(+) T cells and cervicovaginal lavage with potent anti-HIV-1 activity suggest that ProT α variants are innate immune mediators involved in immune surveillance.
- Type
- article
- Published
- 2015-05-01
- Cited by
- 15
- References
- 48
- Access
- Open access
- OpenAlex
- https://openalex.org/W2113647798
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:205135744
Keywords
Biology, Interferon, CD8, Immune system, Virology
References
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- Proteomic exploitation on prothymosin alpha-induced mononuclear cell activation.
- Prothymosin alpha: a ubiquitous polypeptide with potential use in cancer diagnosis and therapy
- Cytokine Synergy: an underappreciated contributor to innate anti-viral immunity
- Immune Responses to HIV and SIV in Mucosal Tissues: “Location, Location, Location”
- Novel Function of Prothymosin Alpha as a Potent Inhibitor of Human Immunodeficiency Virus Type 1 Gene Expression in Primary Macrophages
- Prothymosin alpha and cell death mode switch, a novel target for the prevention of cerebral ischemia-induced damage.
- The human prothymosin alpha gene is polymorphic and induced upon growth stimulation: evidence using a cloned cDNA.
- Upregulation of Interferon-α and RANTES in the Cervix of HIV-1-Seronegative Women With High-Risk Behavior
- Prothymosin-α inhibits HIV-1 via Toll-like receptor 4-mediated type I interferon induction
- Control of HIV-1 infection by soluble factors of the immune response
- Mucosal immune responses to HIV-1 in elite controllers: a potential correlate of immune control.
- GAG triplets as splice acceptors of last resort. An unusual form of alternative splicing in prothymosin alpha pre-mRNA.
- The innate immune system: gatekeeper to the female reproductive tract
- The human prothymosin alpha gene family contains several processed pseudogenes lacking deleterious lesions.
- Acetylation is indispensable for p53 antiviral activity
- Removal of endotoxin from recombinant protein preparations.
Cited by
- Tongue sole (Cynoglossus semilaevis) prothymosin alpha: Cytokine-like activities associated with the intact protein and the C-terminal region that lead to antiviral immunity via Myd88-dependent and -independent pathways respectively.
- Thymosin α 1 potentiates the release by CD8+ cells of soluble factors able to inhibit HIV-1 and human T lymphotropic virus 1 infection in vitro
- Subcellular dissemination of prothymosin alpha at normal physiology: immunohistochemical vis-a-vis western blotting perspective
- Prothymosin Alpha and Immune Responses
- Prothymosin alpha‐deficiency enhances anxiety‐like behaviors and impairs learning/memory functions and neurogenesis
- Prothymosin‐α enhances phosphatase and tensin homolog expression and binds with tripartite motif‐containing protein 21 to regulate Kelch‐like ECH‐associated protein 1/nuclear factor erythroid 2‐related factor 2 signaling in human bladder cancer
- Thymosin participates in antimicrobial immunity in zebrafish
- Systematic evaluation of isoform function in literature reports of alternative splicing
- Identification of Noncanonical Transcripts Produced by Systematic Nucleotide Exchanges in HIV-Associated Centroblastic Lymphoma
- Quality standard of recombinant prothymosin alpha and function in aquatic feed
- Canonical Wnts mediate CD8+ T cell non-cytolytic anti-HIV-1 activity and correlate with HIV-1 clinical status
- The CD8+ T Cell Noncytotoxic Antiviral Responses
- The Effect of Allicin on the Proteome of SARS-CoV-2 Infected Calu-3 Cells
- Overexpression of prothymosin-α in glioma is associated with tumor aggressiveness and poor prognosis
- Effect of prothymosin α on neuroplasticity following cerebral ischemia‑reperfusion injury
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