Intracellular and extracellular cytokine-like functions of prothymosin α: implications for the development of immunotherapies.
Explore this paper's citation graph
Summary
The intracellular function of ProTα is discussed, how new findings of cytokine-like activities ofprothymosin α aid the understanding of mechanisms that direct ProT α functions, and the potential application of these new insights to the development of immunotherapies.
- Type
- article
- Published
- 2011-08-01
- Cited by
- 39
- References
- 116
- OpenAlex
- https://openalex.org/W21806381
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:22332742
Keywords
Humanities, Political science, Art
References
- PURIFICATION AND PROPERTIES OF BOVINE THYMOSIN *
- Kinetics of expression of multiply spliced RNA in early human immunodeficiency virus type 1 infection of lymphocytes and monocytes.
- Prothymosin α restores depressed allogeneic cell‐mediated lympholysis and natural‐killer‐cell activity in patients with cancer
- Large-scale monitoring of host cell gene expression during HIV-1 infection using cDNA microarrays.
- Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence.
- Phytohemagglutin-stimulated human T cell: prothymosin alpha as an accessory signal.
- Thymosin alpha1. SciClone Pharmaceuticals.
- Synthesis and apparent secretion of prothymosin alpha by different subpopulations of calf and rat thymocytes.
- The MYC protein activates transcription of the alpha‐prothymosin gene.
- The thymosins. Prothymosin alpha, parathymosin, and beta-thymosins: structure and function.
- Properties of the protein kinase that phosphorylates prothymosin α
- Prothymosin alpha is phosphorylated in proliferating stimulated cells.
- Inhibition of Rev activity and human immunodeficiency virus type 1 replication by antisense oligodeoxynucleotide phosphorothioate analogs directed against the Rev-responsive element
- Expression of the rat prothymosin alpha gene during T-lymphocyte proliferation and liver regeneration.
- Tumour prothymosin alpha content, a potential prognostic marker for primary breast cancer
- Divalent metal cation binding properties of human prothymosin alpha.
- Cutting Edge: Heat Shock Protein 60 Is a Putative Endogenous Ligand of the Toll-Like Receptor-4 Complex1
- The expression of prothymosin alpha gene in T lymphocytes and leukemic lymphoid cells is tied to lymphocyte proliferation.
- Expression and function of Toll-like receptor on T cells.
- An E-box element localized in the first intron mediates regulation of the prothymosin alpha gene by c-myc
Cited by
- Tongue sole (Cynoglossus semilaevis) prothymosin alpha: Cytokine-like activities associated with the intact protein and the C-terminal region that lead to antiviral immunity via Myd88-dependent and -independent pathways respectively.
- Prothymosin alpha: a ubiquitous polypeptide with potential use in cancer diagnosis and therapy
- Prothymosin α overexpression contributes to the development of pulmonary emphysema
- Specific in vitro binding of a new (99m)Tc-radiolabeled derivative of the C-terminal decapeptide of prothymosin alpha on human neutrophils.
- First evidence of prothymosin alpha localization in the acrosome of mammalian male gametes
- Prothymosin α plays multifunctional cell robustness roles in genomic, epigenetic, and nongenomic mechanisms
- Prothymosin α variants isolated from CD8+ T cells and cervicovaginal fluid suppress HIV-1 replication through type I interferon induction.
- Prothymosin alpha expression and localization during the spermatogenesis of Danio rerio
- Deletion of Nuclear Localizing Signal Attenuates Proinflammatory Activity of Prothymosin-Alpha and Enhances Its Neuroprotective Effect on Transient Ischemic Stroke
- Neuroprotective impact of prothymosin alpha-derived hexapeptide against retinal ischemia-reperfusion.
- Investigation of the Zinc Binding Region of Prothymosin-alpha: A Spectroscopic and Thermodynamic Approach to Study Metal Binding in Intrinsically Disordered Proteins
- Targeting Hsp70: A possible therapy for cancer
- Spatial Cross-Talk between Oxidative Stress and DNA Replication in Human Fibroblasts.
- Prothymosin-α Variants Elicit Anti-HIV-1 Response via TLR4 Dependent and Independent Pathways
- In vivo biodistribution and imaging studies with a 99mTc‐radiolabeled derivative of the C‐terminus of prothymosin alpha in mice bearing experimentally‐induced inflammation
- Prothymosin alpha‐deficiency enhances anxiety‐like behaviors and impairs learning/memory functions and neurogenesis
- Peptidomics Analysis of Transient Regeneration in the Neonatal Mouse Heart
- Prothymosin alpha expression in the vertebrate testis: a comparative review
- Extreme disorder in an ultra-high-affinity protein complex
- Circulating miRNAs as Putative Biomarkers of Exercise Adaptation in Endurance Horses
Related papers
No related papers recorded.