TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells.
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Summary
The data indicate that, in the presence of IL-6, TGFbeta1 subverts Th1 and Th2 differentiation for the generation ofIL-17-producing T cells.
- Type
- article
- Published
- 2006-02-01
- Cited by
- 3,800
- References
- 69
- Access
- Open access
- OpenAlex
- https://openalex.org/W2112866067
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:20446745
Keywords
Biology, IL-2 receptor, Cell biology, Cytokine, Proinflammatory cytokine
References
- Interleukin‐2 is essential for CD4+CD25+ regulatory T cell function
- A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3
- Homeostasis of Peripheral CD4+ T Cells: IL-2Rα and IL-2 Shape a Population of Regulatory Cells That Controls CD4+ T Cell Numbers1
- Identification of Smad7, a TGFβ-inducible antagonist of TGF-β signalling
- Inhibition of transforming growth factor-β/SMAD signalling by the interferon-γ/STAT pathway
- Transforming growth factor-β in T-cell biology
- Regulatory CD4 T Cells Control the Size of the Peripheral Activated/Memory CD4 T Cell Compartment1
- Regulatory T cells in the control of immune pathology
- IL-6 Increases Primed Cell Expansion and Survival
- A novel transcription factor, T-bet, directs Th1 lineage commitment.
- T cells in inflammatory bowel disease: protective and pathogenic roles.
- Reversal of acute and chronic synovial inflammation by anti- transforming growth factor beta
- A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
- TGF‐β1 down‐regulates Th2 development and results in decreased IL‐4‐induced STAT6 activation and GATA‐3 expression
- Toll Pathway-Dependent Blockade of CD4+CD25+ T Cell-Mediated Suppression by Dendritic Cells
- Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self
- Interleukin 6 Is Required for the Development of Collagen-induced Arthritis
- IL-23 drives a pathogenic T cell population that induces autoimmune inflammation
- Neutralization of interleukin-17 aggravates dextran sulfate sodium-induced colitis in mice.
- IL‐6‐deficient mice resist myelin oligodendrocyte glycoprotein‐induced autoimmune encephalomyelitis
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- The Th-17 response and its potential role in post-injury pulmonary complications.
- Dendritic cells and autoimmune heart failure.
- IL-17 family cytokines and the expanding diversity of effector T cell lineages.
- Interferon-gamma regulates susceptibility to collagen-induced arthritis through suppression of interleukin-17.
- Context-dependent regulation of cutaneous immunological responses by TGFbeta1 and its role in skin carcinogenesis.
- Genome‐wide expression profiling during protection from colitis by regulatory T cells
- Pre-transplant Toxoplasma gondii seropositivity among heart transplant recipients is associated with an increased risk of all-cause and cardiac mortality.
- Lyme Arthritis: Current Concepts and a Change in Paradigm
- Th17 T cells: linking innate and adaptive immunity.
- Induction of hsp70-mediated Th17 autoimmunity can be exploited as immunotherapy for metastatic prostate cancer.
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- Regulatory T‐cell immunity and its relevance to atherosclerosis
- Hookworm-Induced Persistent Changes to the Immunological Environment of the Lung
- TPA induction leads to a Th17-like response in transgenic K14/VEGF mice: a novel in vivo screening model of psoriasis.
- Role of mucosal dendritic cells in inflammatory bowel disease.
- Generation and regulation of human CD4+ IL-17-producing T cells in ovarian cancer
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