Inhibition of transforming growth factor-β/SMAD signalling by the interferon-γ/STAT pathway
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Summary
The results indicate a mechanism of transmodulation between the STAT and SMAD signal-transduction pathways that prevents the interaction of Smad3 with the TGF-β receptor.
- Type
- article
- Published
- 1999-02-25
- Cited by
- 767
- References
- 43
- OpenAlex
- https://openalex.org/W1574615823
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:4425637
Keywords
SMAD, STAT1, Phosphorylation, Smad2 Protein, Tyrosine phosphorylation
References
- Complementation of a mutant cell line: central role of the 91 kDa polypeptide of ISGF3 in the interferon‐alpha and ‐gamma signal transduction pathways.
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- Identification of Smad7, a TGFβ-inducible antagonist of TGF-β signalling
- Growth regulation of A431 cells. Modulation of expression of transforming growth factor-alpha mRNA and 2',5'-oligoadenylate synthetase activity.
- Transforming growth factor-beta 1 modulates the expression of class II histocompatibility antigens on human cells.
- Opposing BMP and EGF signalling pathways converge on the TGF-β family mediator Smad1
- TGF-β signalling from cell membrane to nucleus through SMAD proteins
- Induction of dorsal mesoderm by soluble, mature Vg1 protein.
- IFN-gamma and transforming growth factor-beta 1 differently regulate fibronectin and laminin receptors of human differentiating monocytic cells.
- Cytokine receptor signalling
- Two forms of transforming growth factor-β distinguished by multipotential haematopoietic progenitor cells
- Frzb-1 is a secreted antagonist of Wnt signaling expressed in the Spemann organizer.
- A synthetic inhibitor of the mitogen-activated protein kinase cascade.
- Partnership between DPC4 and SMAD proteins in TGF-β signalling pathways
- Receptor-associated Mad homologues synergize as effectors of the TGF-β response
- BMP-2/-4 and Wnt-8 cooperatively pattern the Xenopus mesoderm.
- Tetranucleotide GGGA Motif in Primary RNA Transcripts
- Mixer, a homeobox gene required for endoderm development.
- Effects of 1 alpha,25-dihydroxyvitamin D3 and cytokines on the expression of MHC antigens, complement receptors and other antigens on human blood monocytes and U937 cells: role in cell differentiation, activation and phagocytosis.
Cited by
- Myc Downregulation by Transforming Growth Factor β Required for Activation of the p15Ink4b G1 Arrest Pathway
- Distinct Oligomeric States of SMAD Proteins in the Transforming Growth Factor-β Pathway*
- IFN-gamma gene polymorphisms associate with development of EBV+ lymphoproliferative disease in hu PBL-SCID mice.
- Treatment of idiopathic pulmonary fibrosis: Is there anything new?
- Inhibition of Smad7, a negative regulator of TGF-beta signaling, suppresses autoimmune encephalomyelitis.
- Enhanced expression of interleukin-18 in serum and pancreas of patients with chronic pancreatitis.
- Stromal interaction essential for vascular endothelial growth factor A-induced tumour growth via transforming growth factor-β signalling
- Hepatocyte-specific Smad7 deletion accelerates DEN-induced HCC via activation of STAT3 signaling in mice
- Yangfei Kongliu Formula, a compound Chinese herbal medicine, combined with cisplatin, inhibits growth of lung cancer cells through transforming growth factor-β1 signaling pathway.
- Transforming Growth Factor Beta and breast cancer.
- RUNX1/AML1 functions and mechanisms regulating granulocyte-macrophage colony-stimulating factor transcription
- Tumor-associated EGFR over-expression specifically activates Stat3 and Smad7 resulting in desensitization of TGF-β signaling
- Cytokine-mediated Regulation of BK Virus Replication.
- THE ROLE OF INFLAMMATION IN SKELETAL MUSCLE HEALING
- The IgH locus 3' regulatory region: pulling the strings from behind.
- Growth factor regulation of kinases.
- Transcription in the osteoblast: regulatory mechanisms utilized by parathyroid hormone and transforming growth factor-beta.
- Bone Morphogenetic Protein Receptors in the Nervous System: Neurotrophic Functions With Emphasis on Catecholaminergic Neurons
- Acetylation: a critical factor in maintaining intestinal inflammation?
- Transcriptional Corepressors: Mediators of Eukaryotic Gene Repression
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